New thienoyl-substituted pyrrolo[1,2-c] quinazoline derivatives

被引：15

作者：

Georgescu, Emilian ^{[1
]}

Georgescu, Florentina ^{[1
]}

Roibu, Constantin ^{[1
]}

Iuhas, Paula C. ^{[1
]}

Draghici, Constantin ^{[2
]}

Filip, Petru I. ^{[2
]}

机构：

[1] Res Ctr Oltchim, 1 Uzinei Str, Ramnicu Valcea 240050, Romania

[2] Romanian Acad, Ctr Organ Chem, Bucharest 060023, Romania

来源：

ARKIVOC | 2008年

关键词：

1,3-Dipolar cycloadditions; pyrrolo[1,2-c] quinazoline; 3-(2-thienoylmethyl)-quinazolinium bromide; 3-(2-thienoylmethyl)-4-methoxy-3,4-dihydroquinazolinium bromide;

D O I：

10.3998/ark.5550190.0009.c07

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By the reaction of quinazoline with omega-bromo-2-acethylthiophene in methanol followed by treatment of the intermediate mixture of quaternary salts with unsymmetrical activated alkynes in propenoxide, 3-(2-thienoyl)pyrrolo[1,2-c]quinazoline derivatives were obtained. 3-(2-Thienoyl)pyrrolo[1,2-c]quinazolines were also obtained by an alternative one-pot procedure directly from quinazoline, omega-bromo-2-acetylthiophene and unsymmetrical activated alkynes in propenoxide, by one-pot, multi-step sequences of reactions. Heating the same mixture of quinazolinium salts in the presence of the strong base 1-(2-thienoyl)-2-(2-thienyl)pyrrolo[1,2-c]quinazoline, an interesting inactivation product of the intermediate quinazolinium-3-thienoylmethylide was obtained.

引用

页码：60 / 67

页数：8

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