Metabolism - Bile acids heat things up

被引:17
作者
Baxter, JD
Webb, P
机构
[1] Univ Calif San Francisco, Sch Med, Ctr Diabet, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA 94143 USA
关键词
D O I
10.1038/439402a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Thyroid hormone causes fat loss, but harnessing this action to treat obesity is difficult because it is associated with harmful side effects. However, bile acids generate active thyroid hormone just where it is needed.
引用
收藏
页码:402 / 403
页数:2
相关论文
共 9 条
[1]   Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight [J].
Baxter, JD ;
Webb, P ;
Grover, G ;
Scanlan, TS .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2004, 15 (04) :154-157
[2]   Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes [J].
Gaede, P ;
Vedel, P ;
Larsen, N ;
Jensen, GVH ;
Parving, H ;
Pedersen, O .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (05) :383-393
[3]   Prevalence of overweight and obesity among US children, adolescents, and adults, 1999-2002 [J].
Hedley, AA ;
Ogden, CL ;
Johnson, CL ;
Carroll, MD ;
Curtin, LR ;
Flegal, KM .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (23) :2847-2850
[4]  
IKEMOTO S, 1997, AM J PHYSIOL, V273, P37
[5]  
KALAANY NY, 2005, ANN REV PHYSL
[6]   A G protein-coupled receptor responsive to bile acids [J].
Kawamata, Y ;
Fujii, R ;
Hosoya, M ;
Harada, M ;
Yoshida, H ;
Miwa, M ;
Fukusumi, S ;
Habata, Y ;
Itoh, T ;
Shintani, Y ;
Hinuma, S ;
Fujisawa, Y ;
Fujino, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) :9435-9440
[7]  
SHOENFIELD LJ, 1981, ANN INTERN MED, V95, P257
[8]   Obesity and the regulation of energy balance [J].
Spiegelman, BM ;
Flier, JS .
CELL, 2001, 104 (04) :531-543
[9]   Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation [J].
Watanabe, M ;
Houten, SM ;
Mataki, C ;
Christoffolete, MA ;
Kim, BW ;
Sato, H ;
Messaddeq, N ;
Harney, JW ;
Ezaki, O ;
Kodama, T ;
Schoonjans, K ;
Bianco, AC ;
Auwerx, J .
NATURE, 2006, 439 (7075) :484-489