lnCAR: A Comprehensive Resource for lncRNAs from Cancer Arrays

被引：55

作者：

Zheng, Yueyuan ^{[1
]}

Xu, Qingxian ^{[1
]}

Liu, Mengni ^{[1
]}

Hu, Huanjing ^{[1
]}

Xie, Yubin ^{[1
]}

Zuo, Zhixiang ^{[1
]}

Ren, Jian ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Canc Ctr, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China,Sch Life Sci, Guangzhou, Guangdong, Peoples R China

来源：

CANCER RESEARCH | 2019年 / 79卷 / 08期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

LONG NONCODING RNAS; MANUALLY CURATED DATABASE; HOTAIR;

D O I：

10.1158/0008-5472.CAN-18-2169

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Long noncoding RNAs (lncRNA) have emerged as promising biomarkers in cancer diagnosis, treatment, and prognosis. Recent studies suggest that a large number of coding gene expression microarray probes could be reannotated as lncRNAs. Microarray, once the most cutting-edge high-throughput gene expression technology, has been used for thousands of cancer studies and has brought invaluable resources for studying the functions of lncRNA in cancer development. However, a comprehensive lncRNA resource based on microarray data is still lacking. Here, we present lnCAR (lncRNAs from cancer arrays), a comprehensive open resource for providing expression profiles and prognostic landscape of lncRNAs derived from reannotation of public microarray data. Currently, lnCAR contains 52,300 samples for differential expression analysis and 12,883 samples for survival analysis from 10 cancer types. lnCAR allows users to interactively explore any annotated or novel lncRNAs. We believe lnCAR will serve as a valuable resource for the community focused on lncRNA research in cancer. Significance: lnCAR, a new interactive tool of reannotated public cancer-related microarray data, provides expression profiles and prognostic landscapes of lncRNAs across thousands of samples and multiple cancer types.

引用

页码：2076 / 2083

页数：8

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