Natural and synthetic G-quadruplex interactive berberine derivatives

被引：191
|
作者：
Franceschin, M
Rossetti, L
D'Ambrosio, A
Schirripa, S
Bianco, A
Ortaggi, G
Savino, M
Schultes, C
Neidle, S
机构：
[1] Univ London, Sch Pharm, Canc Res UK Biomol Struct Grp, London WC1N 1AX, England
[2] Univ Roma La Sapienza, Dipartimento Chim, I-00185 Rome, Italy
[3] Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, I-00185 Rome, Italy
[4] Univ Roma La Sapienza, Scuola Specializzaz Sostanze Organ Nat Luigi Pani, I-00185 Rome, Italy
[5] Univ Roma La Sapienza, CNR, Ist Biol & Patol Mol, I-00185 Rome, Italy
[6] Univ Roma La Sapienza, CNR, Ist Chim Biomol, I-00185 Rome, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 06期
关键词：
G-quadruplex; telomerase; alkaloid; berberine;
D O I：
10.1016/j.bmcl.2005.12.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The interaction of the natural alkaloid berberine with various G-quadruplex DNA structures and its ability to inhibit telomerase have been examined and compared with those of a synthetic piperidino derivative and the related compound coralyne. The results show that these molecules have selectivity for G-quadruplex compared to duplex DNA, and that their aromatic moieties play a dominant role in quadruplex binding. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1707 / 1711
页数：5
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