mGlu3 receptor and astrocytes: Partners in neuroprotection

被引：32

作者：

Durand, Daniela ^{[1
]}

Carniglia, Lila ^{[1
]}

Caruso, Carla ^{[1
]}

Lasaga, Mercedes ^{[1
]}

机构：

[1] Univ Buenos Aires, Inst Invest Biomed INBIOMED, Sch Med, CABA, RA-1121 Buenos Aires, DF, Argentina

来源：

NEUROPHARMACOLOGY | 2013年 / 66卷

关键词：

Astrocytes; mGlu3; receptor; Physiopathology; METABOTROPIC GLUTAMATE-RECEPTOR; BRAIN-BARRIER PROPERTIES; CUE-INDUCED REINSTATEMENT; CENTRAL-NERVOUS-SYSTEM; WHITE-MATTER LESIONS; GROUP-II; N-ACETYLASPARTYLGLUTAMATE; AGONIST LY379268; RAT-BRAIN; GROWTH-FACTOR;

D O I：

10.1016/j.neuropharm.2012.04.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Astrocytes are currently studied intensively because of their now highlighted relevance as key players with neurons that modulate a wide range of central functions, from synaptic plasticity and synaptogenesis to regulation of metabolic and neuroinflammatory processes. Since the discovery of mGlu3 receptors on astrocytes, accumulating evidence supports a role of these receptors not only in maintaining synaptic homeostasis and treating psychiatric disorders but also in promoting astrocyte survival in several pathologic conditions. This review focuses on providing up-to-date knowledge regarding effects of activating astroglial mGlu3 receptors on psychiatric disorders, astrocyte and neuronal survival, and neurodegenerative diseases. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'. (c) 2012 Elsevier Ltd. All rights reserved.

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页码：1 / 11

页数：11

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