GI functions of GPR39: novel biology

被引：38
作者：
Depoortere, Inge [1 ]
机构：
[1] Catholic Univ Louvain, B-3000 Louvain, Belgium
来源：
CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 06期
关键词：
PROTEIN-COUPLED RECEPTOR; GROWTH-HORMONE SECRETAGOGUE; ZINC SUPPLEMENTATION; CONSTITUTIVE ACTIVITY; INSULIN-SECRETION; PANCREATIC-ISLETS; GENE-EXPRESSION; RAT ADIPOCYTES; NEUROMEDIN-U; DIETARY ZINC;
D O I：
10.1016/j.coph.2012.07.019
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
GPR39 is an orphan GPCR receptor belonging to the ghrelin/motilin receptor subfamily. The receptor is constitutively active and Zn2+ is a physiological agonist of GPR39. The receptor is emerging as an important regulator of gastrointestinal motility and secretion. Although GPR39 does not seem to be involved in the regulation of food intake, contradictory results are available on the role of GPR39 in the regulation of body weight. A well-established stimulatory role for GPR39 has been defined in insulin secretion which makes the receptor an attractive target for the treatment of type 1 or 2 diabetes. GPR39 signaling also inhibits apoptosis and mediates neural synaptic signaling. Novel ligands of GPR39 are warranted to reveal the main physiological role of this receptor.
引用
收藏
页码：647 / 652
页数：6
相关论文
共 60 条
[1]   Induction of neuronal apoptosis by thiol oxidation: Putative role of intracellular zinc release [J].
Aizenman, E ;
Stout, AK ;
Harnett, KA ;
Dineley, KE ;
McLaughlin, B ;
Reynolds, IJ .
JOURNAL OF NEUROCHEMISTRY, 2000, 75 (05) :1878-1888
[2]   ZINC SUPPLEMENTATION ATTENUATES INSULIN SECRETORY ACTIVITY IN PANCREATIC-ISLETS OF THE OB OB MOUSE [J].
BEGINHEICK, N ;
DALPESCOTT, M ;
ROWE, J ;
HEICK, HMC .
DIABETES, 1985, 34 (02) :179-184
[3]   Synaptically Released Zinc Triggers Metabotropic Signaling via a Zinc-Sensing Receptor in the Hippocampus [J].
Besser, Limor ;
Chorin, Ehud ;
Sekler, Israel ;
Silverman, William F. ;
Atkin, Stan ;
Russell, James T. ;
Hershfinkel, Michal .
JOURNAL OF NEUROSCIENCE, 2009, 29 (09) :2890-2901
[4]   Neuromedin U and its receptors: Structure, function, and physiological roles [J].
Brighton, PJ ;
Szekeres, PG ;
Willars, GB .
PHARMACOLOGICAL REVIEWS, 2004, 56 (02) :231-248
[5]   The obestatin receptor (GPR39) is expressed in human adipose tissue and is down-regulated in obesity-associated type 2 diabetes mellitus [J].
Catalan, V. ;
Gomez-Ambrosi, J. ;
Rotellar, F. ;
Silva, C. ;
Gil, M. J. ;
Rodriguez, A. ;
Cienfuegos, J. A. ;
Salvador, J. ;
Fruehbeck, G. .
CLINICAL ENDOCRINOLOGY, 2007, 66 (04) :598-601
[6]   Comment on "Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake" [J].
Chartrel, N. ;
Alvear-Perez, R. ;
Leprince, J. ;
Iturrioz, X. ;
Reaux-Le Goazigo, A. ;
Audinot, V. ;
Chomarat, P. ;
Coge, F. ;
Nosjean, O. ;
Rodriguez, M. ;
Galizzi, J. P. ;
Boutin, J. A. ;
Vaudry, H. ;
Llorens-Cortes, C. .
SCIENCE, 2007, 315 (5813)
[7]   Effects of zinc supplementation on the plasma glucose level and insulin activity in genetically obese (ob/ob) mice [J].
Chen, MD ;
Liou, SJ ;
Lin, PY ;
Yang, VC ;
Alexander, PS ;
Lin, WH .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1998, 61 (03) :303-311
[8]   Zinc supplementation aggravates body fat accumulation in genetically obese mice and dietary-obese mice [J].
Chen, MD ;
Lin, PY ;
Cheng, V ;
Lin, WH .
BIOLOGICAL TRACE ELEMENT RESEARCH, 1996, 52 (02) :125-132
[9]   Upregulation of KCC2 Activity by Zinc-Mediated Neurotransmission via the mZnR/GPR39 Receptor [J].
Chorin, Ehud ;
Vinograd, Ofir ;
Fleidervish, Ilya ;
Gilad, David ;
Herrmann, Sharon ;
Sekler, Israel ;
Aizenman, Elias ;
Hershfinkel, Michal .
JOURNAL OF NEUROSCIENCE, 2011, 31 (36) :12916-12926
[10]   The truncated ghrelin receptor polypeptide (GHS-R1b) is localized in the endoplasmic reticulum where it forms heterodimers with ghrelin receptors (GHS-R1a) to attenuate their cell surface expression [J].
Chow, Kevin B. S. ;
Sun, Jingxin ;
Chu, Kit Man ;
Cheung, Wing Tai ;
Cheng, Christopher H. K. ;
Wise, Helen .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 348 (01) :247-254
123456