Immunotherapy in gastrointestinal cancer: The current scenario and future perspectives

被引：59

作者：

Abdul-Latif, Mohammed ^{[1
]}

Townsend, Katherine ^{[2
]}

Dearman, Charles ^{[2
]}

Shiu, Kai-Keen ^{[3
]}

Khan, Khurum ^{[1
,3
]}

机构：

[1] North Middlesex Univ Hosp, Dept Oncol, Sterling Way, London N18 1QX, England

[2] Royal Marsden, Fulham Rd, London SW3 6JJ, England

[3] UCL, Canc Inst, Dept Med Oncol, 72 Huntly St, London WC1E 6AG, England

来源：

CANCER TREATMENT REVIEWS | 2020年 / 88卷

关键词：

Immunotherapy; Gastrointestinal cancer; Review; Oesophageal; Gastric; Pancreatic; Colorectal; Hepatic; Biliary; Checkpoint inhibition; Vaccine; Adoptive cell therapy; T-CELL THERAPY; COMPREHENSIVE MOLECULAR CHARACTERIZATION; MISMATCH REPAIR-DEFICIENT; INDUCED KILLER-CELLS; HEPATOCELLULAR-CARCINOMA; COLORECTAL-CANCER; MICROSATELLITE INSTABILITY; SOLID TUMORS; PHASE-I; RECOMBINANT INTERLEUKIN-2;

D O I：

10.1016/j.ctrv.2020.102030

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastrointestinal cancers include colorectal, gastric, oesophageal, pancreatic and liver cancers. They continue to be a significant cause of mortality and morbidity worldwide. Current treatment strategies include chemotherapy, surgery, radiotherapy and targeted therapies. Immunotherapy has recently been incorporated in treatment regimens for some gastrointestinal malignancies and research into different immune modifying treatments is being carried out in this context. Approaches to immune modulation such as vaccination, adoptive cell therapy and checkpoint inhibition have shown varying clinical benefit, with most of the benefit seen in checkpoint inhibition. This review summarises recent advances and future direction of immunotherapy in patients with gastrointestinal malignancies.

引用

页数：18

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