Sperm chromatin structure and male fertility: biological and clinical aspects

被引：203
作者：
Erenpreiss, J [1 ]
Spano, M
Erenpreisa, J
Bungum, M
Giwercman, A
机构：
[1] Lund Univ, Malmo Univ Hosp, Fertil Ctr, SE-20502 Malmo, Sweden
[2] Latvian Univ Biomed Ctr, LV-1067 Riga, Latvia
[3] ENEA CR Casaccia, BIOTEC MED, Sect Toxicol & Biomed Sci, I-00060 Rome, Italy
[4] Viborg Hosp, Fertil Clin, DK-7800 Skive, Denmark
来源：
ASIAN JOURNAL OF ANDROLOGY | 2006年 / 8卷 / 01期
关键词：
infertility; sperm; DNA damage; human;
D O I：
10.1111/j.1745-7262.2006.00112.x
中图分类号：
R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
摘要：
Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal genetic information, and normal sperm chromatin structure is important for sperm fertilizing ability. The routine examination of semen, which includes sperm concentration, motility and morphology, does not identify defects in sperm chromatin structure. The origin of sperm DNA damage and a variety of methods for its assessment are described. Evaluation of sperm DNA damage appears to be a useful tool for assessing male fertility potential both in vivo and in vitro. The possible impact of sperm DNA defects on the offspring is also discussed.
引用
收藏
页码：11 / 29
页数：19
相关论文
共 190 条
  • [71] Study of apoptotic DNA fragmentation in human spermatozoa
    Gandini, L
    Lombardo, F
    Paoli, D
    Caponecchia, L
    Familiari, G
    Verlengia, C
    Dondero, F
    Lenzi, A
    [J]. HUMAN REPRODUCTION, 2000, 15 (04) : 830 - 839
  • [72] Full-term pregnancies achieved with ICSI despite high levels of sperm chromatin damage
    Gandini, L
    Lombardo, F
    Paoli, D
    Caruso, F
    Eleuteri, P
    Leter, G
    Ciriminna, R
    Culasso, F
    Dondero, F
    Lenzi, A
    Spanò, M
    [J]. HUMAN REPRODUCTION, 2004, 19 (06) : 1409 - 1417
  • [73] SEQUENCE-SPECIFIC PACKAGING OF DNA IN HUMAN-SPERM CHROMATIN
    GATEWOOD, JM
    COOK, GR
    BALHORN, R
    BRADBURY, EM
    SCHMID, CW
    [J]. SCIENCE, 1987, 236 (4804) : 962 - 964
  • [74] GENESCA A, 1992, HUM GENET, V89, P181
  • [75] Correlation between sperm motility and sperm chromatin structure assay parameters
    Giwercman, A
    Richthoff, J
    Hjollund, H
    Bonde, JP
    Jepson, K
    Frohm, B
    Spano, M
    [J]. FERTILITY AND STERILITY, 2003, 80 (06) : 1404 - 1412
  • [76] PRESENCE OF DNA STRAND BREAKS AND INCREASED SENSITIVITY OF DNA IN-SITU TO DENATURATION IN ABNORMAL HUMAN SPERM CELLS - ANALOGY TO APOPTOSIS OF SOMATIC-CELLS
    GORCZYCA, W
    TRAGANOS, F
    JESIONOWSKA, H
    DARZYNKIEWICZ, Z
    [J]. EXPERIMENTAL CELL RESEARCH, 1993, 207 (01) : 202 - 205
  • [77] ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment
    Greco, E
    Romano, S
    Iacobelli, M
    Ferrero, S
    Baroni, E
    Minasi, MG
    Ubaldi, F
    Rienzi, L
    Tesarik, J
    [J]. HUMAN REPRODUCTION, 2005, 20 (09) : 2590 - 2594
  • [78] Haines G, 1998, ADV EXP MED BIOL, V444, P79
  • [79] Hammadeh ME, 1998, ANDROLOGIA, V30, P29
  • [80] The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization.
    Hansen, M
    Kurinczuk, JJ
    Bower, C
    Webb, S
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (10) : 725 - 730
3456789101112