Multi Targeted CAR-T Cell Therapies for B-Cell Malignancies

被引：145

作者：

Shah, Nirav N. ^{[1
]}

Maatman, Theresa ^{[2
]}

Hari, Parameswaran ^{[1
]}

Johnson, Bryon ^{[1
]}

机构：

[1] Med Coll Wisconsin, Div Hematol & Oncol, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

来源：

FRONTIERS IN ONCOLOGY | 2019年 / 9卷

关键词：

CAR-T; antigen escape; B-cell NHL; B-cell ALL; immunotherapy; ANTIGEN ESCAPE; RECEPTOR; EFFICACY; RESISTANCE; LEUKEMIA;

D O I：

10.3389/fonc.2019.00146

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chimeric antigen receptor (CAR) modified T cell therapy has revolutionized the treatment of relapsed and refractory hematological malignancies. Through targeting of the CD19 antigen on B cells durable remissions have been achieved in patients with B cell non-Hodgkin lymphoma and acute lymphoblastic lymphoma. Despite impressive responses, multiple escape mechanisms to evade CAR-T cell therapy have been identified, among which the most common is loss of the target antigen. In this review we will highlight outcomes to date with CD19 CAR-T cell therapy, describe the current limitations of single targeted CAR-T therapies, review identified tumor escape mechanisms, and lastly discuss novel strategies to overcome resistance via multi-targeted CAR-T cells.

引用

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