Targeting Strategies for Human Immunodeficiency Virus: A Combinatorial Approach

被引：0

作者：

Saxena, S. K. ^{[1
]}

Gupta, A. ^{[2
]}

Bhagyashree, K. ^{[2
]}

Saxena, R. ^{[1
]}

Arora, N. ^{[1
]}

Banerjee, A. K. ^{[3
]}

Tripathi, A. K. ^{[4
]}

Chandrasekar, M. J. N. ^{[2
]}

Gandhi, N. ^{[5
]}

Nair, M. P. N. ^{[5
]}

机构：

[1] CSIR, Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India

[2] JSS Coll Pharm, Ootacamund 643001, India

[3] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

[4] CSM Med Univ, HIV AIDS Clin, Dept Med, KGs Med Coll, Lucknow 226024, Uttar Pradesh, India

[5] Florida Int Univ, Coll Med, Miami, FL 33199 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2012年 / 12卷 / 03期

关键词：

Lentivirus; HIV; host cellular target; life cycle; treatment; nucleoside; reverse transcriptase; protease; integrase; carbohydrate binding proteins; Griffithsin; synthesis; inhibitors; RESTRICTS HIV-1 INFECTION; SURFACE CD4 EXPRESSION; CYTOPLASMIC DOMAIN; RAPID DEGRADATION; HUMAN TRIM5-ALPHA; DOWN-REGULATION; VIF PROTEIN; TYPE-1; NEF; VPU;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The battle between human and the Human immunodeficiency virus (HIV) is on, with both of them rapidly improving their attacking and defense strategies. Many therapeutic agents for HIV infection have been designed and developed, However there are various aspects, like novel targets against HIV, which are yet to be unfolded with a goal of designing and developing novel drug molecules against HIV. This article reviews the current status and innovative new options for antiretroviral therapy for HIV and also discusses the various mechanisms of action for each class of drugs, and the problems yet to be solved with respect to HIV as a target for improvised treatment against AIDS.

引用

页码：236 / 254

页数：19

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