Targeting Strategies for Human Immunodeficiency Virus: A Combinatorial Approach

被引:0
作者
Saxena, S. K. [1 ]
Gupta, A. [2 ]
Bhagyashree, K. [2 ]
Saxena, R. [1 ]
Arora, N. [1 ]
Banerjee, A. K. [3 ]
Tripathi, A. K. [4 ]
Chandrasekar, M. J. N. [2 ]
Gandhi, N. [5 ]
Nair, M. P. N. [5 ]
机构
[1] CSIR, Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India
[2] JSS Coll Pharm, Ootacamund 643001, India
[3] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
[4] CSM Med Univ, HIV AIDS Clin, Dept Med, KGs Med Coll, Lucknow 226024, Uttar Pradesh, India
[5] Florida Int Univ, Coll Med, Miami, FL 33199 USA
关键词
Lentivirus; HIV; host cellular target; life cycle; treatment; nucleoside; reverse transcriptase; protease; integrase; carbohydrate binding proteins; Griffithsin; synthesis; inhibitors; RESTRICTS HIV-1 INFECTION; SURFACE CD4 EXPRESSION; CYTOPLASMIC DOMAIN; RAPID DEGRADATION; HUMAN TRIM5-ALPHA; DOWN-REGULATION; VIF PROTEIN; TYPE-1; NEF; VPU;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The battle between human and the Human immunodeficiency virus (HIV) is on, with both of them rapidly improving their attacking and defense strategies. Many therapeutic agents for HIV infection have been designed and developed, However there are various aspects, like novel targets against HIV, which are yet to be unfolded with a goal of designing and developing novel drug molecules against HIV. This article reviews the current status and innovative new options for antiretroviral therapy for HIV and also discusses the various mechanisms of action for each class of drugs, and the problems yet to be solved with respect to HIV as a target for improvised treatment against AIDS.
引用
收藏
页码:236 / 254
页数:19
相关论文
共 103 条
  • [1] TRIM5αrh expression restricts HIV-1 infection in lentiviral vector-transduced CD34+-cell-derived macrophages
    Anderson, J
    Akkina, R
    [J]. MOLECULAR THERAPY, 2005, 12 (04) : 687 - 696
  • [2] NEF FROM PRIMARY ISOLATES OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SUPPRESSES SURFACE CD4 EXPRESSION IN HUMAN AND MOUSE T-CELLS
    ANDERSON, S
    SHUGARS, DC
    SWANSTROM, R
    GARCIA, JV
    [J]. JOURNAL OF VIROLOGY, 1993, 67 (08) : 4923 - 4931
  • [3] A retrovirus restriction factor TRIM5α is transcriptionally regulated by interferons
    Asaoka, K
    Ikeda, K
    Hishinuma, T
    Horie-Inoue, K
    Takeda, S
    Inoue, S
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 338 (04) : 1950 - 1956
  • [4] Inhibition of HIV entry by carbohydrate-binding proteins
    Balzarini, J.
    [J]. ANTIVIRAL RESEARCH, 2006, 71 (2-3) : 237 - 247
  • [5] HIV as the cause of AIDS
    BarreSinoussi, F
    [J]. LANCET, 1996, 348 (9019) : 31 - 35
  • [6] INFLUENCE OF CARBOHYDRATE MOIETIES ON THE IMMUNOGENICITY OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 RECOMBINANT GP160
    BENJOUAD, A
    GLUCKMAN, JC
    ROCHAT, H
    MONTAGNIER, L
    BAHRAOUI, E
    [J]. JOURNAL OF VIROLOGY, 1992, 66 (04) : 2473 - 2483
  • [7] DOWN-REGULATION OF CELL-SURFACE CD4 EXPRESSION BY SIMIAN IMMUNODEFICIENCY VIRUS NEF PREVENTS VIRAL SUPER INFECTION
    BENSON, RE
    SANFRIDSON, A
    OTTINGER, JS
    DOYLE, C
    CULLEN, BR
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) : 1561 - 1566
  • [8] Chemokine receptors as HIV-1 coreceptors: Roles in viral entry, tropism, and disease
    Berger, EA
    Murphy, PM
    Farber, JM
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 657 - 700
  • [9] APOBEC-mediated editing of viral RNA
    Bishop, KN
    Holmes, RK
    Sheehy, AM
    Malim, MH
    [J]. SCIENCE, 2004, 305 (5684) : 645 - 645
  • [10] BOTARELLI P, 1991, J IMMUNOL, V147, P3128