Apolipoprotein E polymorphism is not associated with lipid levels and coronary artery disease in Greek patients with familial hypercholesterolaemia

被引:20
作者
Pitsavos, C
Choumerianou, DM
Skoumas, J
Maumus, S
Stefanadis, C
Dedoussis, GVZ
Visvikis-Siest, S
机构
[1] Harokopio Univ Athens, Dept Sci Dietet Nutr, Mol Biol Lab, Kallithea Athens 17671, Greece
[2] Hippocratio Hosp, Med Sch Athens, Hyperlipidem Clin, Dept Cardiol, Athens, Greece
[3] Univ Nancy 1, Fac Pharm, Ctr Medicament, INSERM,U525,Equipe 4, Nancy, France
关键词
apolipoprotein E; E4; allele; familial hypercholesterolaemia; lipids; coronary artery disease;
D O I
10.1007/s10238-005-0086-z
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Familial hypercholesterolaemia is a genetic disorder characterised by high low-density lipoprotein (LDL) cholesterol concentrations, which frequently gives rise to premature coronary artery disease (CAD). The clinical expression of familial hypercholesterolaemia is highly variable even in patients carrying the same LDL receptor gene mutation. This variability may be due to environmental and other genetic factors. Apolipoprotein E (Apo-E) has been extensively studied for its effects on the phenotype of familial hypercholesterolaemia. In this study we examined the influence of Apo-E genotype on lipid parameters and the incidence of CAD in 93 Greek patients with familial hypercholesterolaemia. Apo-E E2, E3 and E4 allele frequencies were 0.06, 0.86 and 0.09 respectively. The levels of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, apolipoproteins A and B and lipoprotein alpha did not differ significantly among carriers and non-carriers of the E4 allele. The prevalence of CAD and hypertension did not differ either. Our results suggest that the E4 allele is not associated with lipid levels or with the prevalence of CAD among familial hypercholesterolaemia patients of the Greek population.
引用
收藏
页码:196 / 201
页数:6
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