Expression and Functional Relevance of Cannabinoid Receptor 1 in Hodgkin Lymphoma

被引：25

作者：

Benz, Alexander H. ^{[1
,2
]}

Renne, Christoph ^{[2
]}

Maronde, Erik ^{[3
]}

Koch, Marco ^{[4
]}

Grabiec, Urszula ^{[5
]}

Kallendrusch, Sonja ^{[4
]}

Rengstl, Benjamin ^{[2
]}

Newrzela, Sebastian ^{[2
]}

Hartmann, Sylvia ^{[2
]}

Hansmann, Martin-Leo ^{[2
]}

Dehghani, Faramarz ^{[3
,5
]}

机构：

[1] Univ Giessen, Inst Pathol, D-35390 Giessen, Germany

[2] Goethe Univ Frankfurt, Inst Pathol, D-60054 Frankfurt, Germany

[3] Goethe Univ Frankfurt, Inst Anat, D-60054 Frankfurt, Germany

[4] Univ Leipzig, Inst Anat, D-04109 Leipzig, Germany

[5] Univ Halle Wittenberg, Dept Anat & Cell Biol, D-06108 Halle, Germany

来源：

PLOS ONE | 2013年 / 8卷 / 12期

关键词：

CANCER CELL-GROWTH; FACTOR-KAPPA-B; CB1; RECEPTOR; ALPHA-GENE; ANTAGONIST RIMONABANT; HIGH-LEVEL; INHIBITION; DISEASE; MUTATIONS; OVEREXPRESSION;

D O I：

10.1371/journal.pone.0081675

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Cannabinoid receptor 1 (CB1) is expressed in certain types of malignancies. An analysis of CB1 expression and function in Hodgkin lymphoma (HL), one of the most frequent lymphomas, was not performed to date. Design and Methods: We examined the distribution of CB1 protein in primary cases of HL. Using lymphoma derived cell lines, the role of CB1 signaling on cell survival was investigated. Results: A predominant expression of CB1 was found in Hodgkin-Reed-Sternberg cells in a vast majority of classical HL cases. The HL cell lines L428, L540 and KM-H2 showed strong CB1-abundance and displayed a dose-dependent decline of viability under CB1 inhibition with AM251. Further, application of AM251 led to decrease of constitutively active NF kappa B/p65, a crucial survival factor of HRS-cells, and was followed by elevation of apoptotic markers in HL cells. Conclusions: The present study identifies CB1 as a feature of HL, which might serve as a potential selective target in the treatment of Hodgkin lymphoma.

引用

页数：9

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