De Novo Synthesis of Multisubstituted Aryl Amines Using Alkene Cross Metathesis

被引：16

作者：

Tatton, Matthew R. ^{[1
]}

Simpson, Iain ^{[2
]}

Donohoe, Timothy J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

[2] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

RING-CLOSING METATHESIS; COUPLING REACTIONS; CRYSTAL-STRUCTURES; AROMATIC-AMINES; CUPRIC ACETATE; C-N; ENAMINES; REFINEMENT; CONVERSION; ALDEHYDES;

D O I：

10.1021/ol500441q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The olefin cross-metathesis reaction allows rapid access to 1,5-dicarbonyl intermediates which, upon treatment with a primary or secondary amine, allow the synthesis of a range of multisubstituted carbocyclic aryl amines. This de novo arene synthesis yields nonclassical substitution patterns in a regioselective and predictable approach that is compatible with several functional groups.

引用

页码：1920 / 1923

页数：4

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