Correlation of immunohistochemically detected HER-2/neu (c-erbB-2) with histological stage and perineural invasion in pancreatic cancer

被引：0

作者：

Tamiolakis, D

Venizelos, I

Simopoulos, C

Kotini, A

Jivannakis, T

Papadopoulos, N ^{[1
]}

机构：

[1] Democritus Univ Thrace, Dept Expt Surg, Alexandroupolis 68100, Greece

[2] Democritus Univ Thrace, Dept Med Phys, Alexandroupolis 68100, Greece

[3] Democritus Univ Thrace, Dept Histol Embryol, Alexandroupolis 68100, Greece

[4] Ippokrat Hosp Salonica, Dept Pathol, Thessaloniki, Greece

[5] Gen Hosp Chania, Dept Cytol, Iraklion, Greece

[6] Gen Hosp Drama, Dept Pathol, Drama, Greece

来源：

HEPATO-GASTROENTEROLOGY | 2004年 / 51卷 / 56期

关键词：

immunohistochemistry; HER-2/neu oncoprotein; histological stage; perineural invasion; pancreatic cancer;

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: HER-2/neu (c-erbB-2) oncoprotem is a transmembrane glycoprotein and may function as a growth factor being involved in the regulation of cell growth and cell transformation. c-erbB-2 was correlated with established outcome factors in pancreatic cancer. Methodology: We performed an analysis of 100 patients with pancreatic cancer using an immuno-peroxidase technique on formalin-fixed, paraffin-embedded tissue samples in order to determine HER-2/neu oncoprotein expression along with stage and perineural involvement. Results: HER-2/neu oncoprotein was expressed in the tumors of 21 patients (21%). Conclusions: Histologic stage, and perineural invasion did not correlate with HER-2/neu oncoprotein.

引用

页码：334 / 337

页数：4

共 33 条

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