Prevalence of Cardiovascular Autonomic Neuropathy in a Cohort of Patients With Newly Diagnosed Type 2 Diabetes: The Verona Newly Diagnosed Type 2 Diabetes Study (VNDS)

被引：60

作者：

Zoppini, Giacomo ^{[1
]}

Cacciatori, Vittorio ^{[1
]}

Raimondo, Daniele ^{[1
]}

Gemma, Marialuisa ^{[1
]}

Trombetta, Maddalena ^{[1
]}

Dauriz, Marco ^{[1
]}

Brangani, Corinna ^{[1
]}

Pichiri, Isabella ^{[1
]}

Negri, Carlo ^{[1
]}

Stoico, Vincenzo ^{[1
]}

Bergamini, Corinna ^{[2
,3
]}

Targher, Giovanni ^{[1
]}

Santi, Lorenza ^{[1
]}

Thomaseth, Karl ^{[4
]}

Bellavere, Federico ^{[4
]}

Bonadonna, Riccardo C. ^{[1
]}

Bonora, Enzo ^{[1
]}

机构：

[1] Univ Verona, Azienda Osped Univ Integrata, Dept Med, Sect Endocrinol Diabet & Metab, I-37100 Verona, Italy

[2] Univ Verona, Dept Med, Sect Cardiol, I-37100 Verona, Italy

[3] Azienda Osped Univ Integrata Verona, Verona, Italy

[4] CNR, Inst Bioengn, Padua, Italy

来源：

DIABETES CARE | 2015年 / 38卷 / 08期

关键词：

GLUCOSE-TOLERANCE; IMPACT; ASSOCIATION; DISEASE; MELLITUS; PEOPLE;

D O I：

10.2337/dc15-0081

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE Cardiovascular autonomic diabetic neuropathy (CAN) is a serious complication of diabetes. No reliable data on the prevalence of CAN among patients with newly diagnosed type 2 diabetes are available. Therefore, the aim of this study was to estimate the prevalence of CAN among patients with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS A cohort of 557 patients with newly diagnosed type 2 diabetes with cardiovascular autonomic test results available was selected. Early and confirmed neuropathy were assessed using a standardized methodology and their prevalences determined. A multivariate logistic regression analysis was modeled to study the factors associated with CAN. RESULTS In the entire cohort, the prevalence of confirmed CAN was 1.8%, whereas that of early CAN was 15.3%. Prevalence did not differ between men and women. In the multivariate analyses BMI results were independently and significantly associated with CAN after adjusting for age, sex, hemoglobin A(1c), pulse pressure, triglyceride-to-HDL cholesterol ratio, kidney function parameters, and antihypertensive treatment. CONCLUSIONS CAN could be detected very early in type 2 diabetes. This study may suggest the importance of performing standardized cardiovascular autonomic tests after diagnosis of type 2 diabetes.

引用

页码：1487 / 1493

页数：7

共 40 条

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