Alternative lifestyles of T cells

被引：9
作者：
Tato, Cristina M. [1 ]
Cua, Daniel J. [1 ]
机构：
[1] Schering Plough Biopharma, DNAX Res, Palo Alto, CA 94304 USA
来源：
NATURE IMMUNOLOGY | 2008年 / 9卷 / 12期
关键词：
D O I：
10.1038/ni1208-1323
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T cells are intrinsically more malleable than previously thought. Two studies now show that existing T helper type 2 cells can be converted into alternative CD4(+) T helper cells that coexpress interleukins 9 and 10.
引用
收藏
页码：1323 / 1325
页数：4
相关论文
共 10 条
  • [1] The Trichuris muris system:: a paradigm of resistance and susceptibility to intestinal nematode infection
    Cliffe, LJ
    Grencis, RK
    [J]. ADVANCES IN PARASITOLOGY, VOL 57, 2004, 57 : 255 - 307
  • [2] IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3- effector T cells
    Dardalhon, Valerie
    Awasthi, Amit
    Kwon, Hyoung
    Galileos, George
    Gao, Wenda
    Sobel, Raymond A.
    Mitsdoerffer, Meike
    Strom, Terry B.
    Elyaman, Wassim
    Ho, I-Cheng
    Khoury, Samia
    Oukka, Mohamed
    Kuchroo, Vijay K.
    [J]. NATURE IMMUNOLOGY, 2008, 9 (12) : 1347 - 1355
  • [3] Interleukin-23 restrains regulatory T cell activity to drive T cell-dependent colitis
    Izcue, Ana
    Hue, Sophie
    Buonocore, Sofia
    Arancibia-Carcamo, Carolina V.
    Ahern, Philip P.
    Iwakura, Yoichiro
    Maloy, Kevin J.
    Powrie, Fiona
    [J]. IMMUNITY, 2008, 28 (04) : 559 - 570
  • [4] GATA3-driven Th2 responses inhibit TGF-β1-induced FOXP3 expression and the formation of regulatory T cells
    Mantel, Pierre-Yves
    Kuipers, Harmjan
    Boyman, Onur
    Rhyner, Claudio
    Ouaked, Nadia
    Ruckert, Beateru
    Karagiannidis, Christian
    Lambrecht, Bart N.
    Hendriks, Rudolf W.
    Crameri, Reto
    Akdis, Cezmi A.
    Blaser, Kurt
    Schmidt-Weber, Carsten B.
    [J]. PLOS BIOLOGY, 2007, 5 (12): : 2847 - 2861
  • [5] Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    Mucida, Daniel
    Park, Yunji
    Kim, Gisen
    Turovskaya, Olga
    Scott, Iain
    Kronenberg, Mitchell
    Cheroutre, Hilde
    [J]. SCIENCE, 2007, 317 (5835) : 256 - 260
  • [6] Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
    Murphy, E
    Shibuya, K
    Hosken, N
    Openshaw, P
    Maino, V
    Davis, K
    Murphy, K
    OGarra, A
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (03) : 901 - 913
  • [7] T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable?
    John J O'Shea
    Christopher A Hunter
    Ronald N Germain
    [J]. Nature Immunology, 2008, 9 (5) : 450 - 453
  • [8] Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    Veldhoen, Marc
    Uyttenhove, Catherine
    van Snick, Jacques
    Helmby, Helena
    Westendorf, Astrid
    Buer, Jan
    Martin, Bruno
    Wilhelm, Christoph
    Stockinger, Brigitta
    [J]. NATURE IMMUNOLOGY, 2008, 9 (12) : 1341 - 1346
  • [9] Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells
    Wei, Jun
    Duramad, Omar
    Perng, Olivia A.
    Reiner, Steven L.
    Liu, Yong-Jun
    Qin, F. Xiao-Feng
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (46) : 18169 - 18174
  • [10] TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
    Zhou, Liang
    Lopes, Jared E.
    Chong, Mark M. W.
    Ivanov, Ivaylo I.
    Min, Roy
    Victora, Gabriel D.
    Shen, Yuelei
    Du, Jianguang
    Rubtsov, Yuri P.
    Rudensky, Alexander Y.
    Ziegler, Steven F.
    Littman, Dan R.
    [J]. NATURE, 2008, 453 (7192) : 236 - U14
1