Accelerated lung aging and chronic obstructive pulmonary disease

被引：23

作者：

Yoon, Young Soon ^{[1
,2
,3
]}

Jin, Minhee ^{[1
,2
]}

Sin, Don D. ^{[1
,2
,4
]}

机构：

[1] St Pauls Hosp, Ctr Heart & Lung Innovat, 1081 Burrard St, Vancouver, BC, Canada

[2] Univ British Columbia, 1081 Burrard St, Vancouver, BC, Canada

[3] Dongguk Univ, Ilsan Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Goyang, South Korea

[4] Univ British Columbia, Div Resp Med, Dept Med, Vancouver, BC, Canada

来源：

EXPERT REVIEW OF RESPIRATORY MEDICINE | 2019年 / 13卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Chronic obstructive pulmonary disease; aging; senescence; ENDOTHELIAL PROGENITOR CELLS; DIFFERENTIATION FACTOR 11; INCREASED DNA-DAMAGE; CELLULAR SENESCENCE; TELOMERE LENGTH; STEM-CELLS; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; CIRCULATING LEUKOCYTES; SYSTEMIC INFLAMMATION;

D O I：

10.1080/17476348.2019.1580576

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction: The prevalence of chronic obstructive pulmonary disease (COPD) increases exponentially with aging. Its pathogenesis, however, is not well known and aside from smoking cessation, there are no disease-modifying treatments for this disease. Areas covered: COPD is associated with accelerating aging and aging-related diseases. In this review, we will discuss the hallmarks of aging including genomic instability, telomere attrition, epigenetic alteration, loss of proteostasis, mitochondrial dysfunction, deregulated nutrient sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication, which may be involved in COPD pathogenesis. Expert commentary: COPD and the aging process share similar molecular and cellular changes. Aging-related molecular pathways may represent novel therapeutic targets and biomarkers for COPD.

引用

页码：369 / 380

页数：12

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