In vitro activity of aminoglycosides against clinical isolates of Acinetobacter baumannii complex and other nonfermentative Gram-negative bacilli causing healthcare-associated bloodstream infections in Taiwan

被引:13
作者
Liu, Jyh-You [1 ]
Wang, Fu-Der [1 ,2 ,3 ]
Ho, Mao-Wang [4 ]
Lee, Chen-Hsiang [5 ]
Liu, Jien-Wei [5 ]
Wang, Jann-Tay [1 ,2 ,6 ]
Sheng, Wang-Huei [1 ,2 ,6 ]
Hseuh, Po-Ren [1 ,2 ]
Chang, Shan-Chwen [1 ,2 ,6 ]
机构
[1] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 100, Taiwan
[2] Natl Taiwan Univ Coll Med, Dept Internal Med, Taipei, Taiwan
[3] Taipei Vet Gen Hosp, Dept Internal Med, Taipei, Taiwan
[4] China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan
[5] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Kaohsiung, Taiwan
[6] Natl Taiwan Univ Hosp, Infect Control Ctr, Taipei, Taiwan
关键词
Acinetobacter baumannii; Acinetobacter nosocomialis; Acinetobacter pittii; aminoglycosides; antimicrobial susceptibility testing; nonfermentative Gram-negative bacilli; ANTIMICROBIAL SUSCEPTIBILITY; PSEUDOMONAS-AERUGINOSA; MULTIDRUG-RESISTANCE; UNITED-STATES; SURVEILLANCE; BACTERIA; IDENTIFICATION; EPIDEMIOLOGY; MECHANISMS; ISEPAMICIN;
D O I
10.1016/j.jmii.2015.07.010
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background/Purpose: Aminoglycosides possess in vitro activity against aerobic and facultative Gram-negative bacilli. However, nationwide surveillance on susceptibility data of Acinetobacter baumannii complex and Pseudomonas aeruginosa to aminoglycosides was limited, and aminoglycoside resistance has emerged in the past decade. We study the in vitro susceptibility of A. baumannii complex and other nonfermentative Gram-negative bacilli (NFGNB) to aminoglycosides. Methods: A total of 378 NFGNB blood isolates causing healthcare-associated bloodstream infections during 2008 and 2013 at four medical centers in Taiwan were tested for their susceptibilities to four aminoglycosides using the agar dilution method (gentamicin, amikacin, tobramycin, and isepamicin) and disc diffusion method (isepamicin). Results: A. baumannii was highly resistant to all four aminoglycosides (range of susceptibility, 0-4%), whereas >80% of Acinetobacter nosocomialis and Acinetobacter pittii blood isolates were susceptible to amikacin (susceptibility: 96% and 91%, respectively), tobramycin (susceptibility: 92% and 80%, respectively), and isepamicin (susceptibility: 96% and 80%, respectively). All aminoglycosides except gentamicin possessed good in vitro activity (>94%) against P. aeruginosa. Amikacin has the best in vitro activity against P. aeruginosa (susceptibility, 98%), followed by A. nosocomialis (96%), and A. pittii (91%), whereas tobramycin and isepamicin were less potent against A. pittii (both 80%). Aminoglycoside resistances were prevalent in Stenotrophomonas maltophilia and Burkholderia cepacia complex blood isolates in Taiwan. Conclusion: Genospecies among the A. baumannii complex had heterogeneous susceptibility profiles to aminoglycosides. Aminoglycosides, except gentamicin, remained good in vitro antimicrobial activity against P. aeruginosa. Further in vivo clinical data and continuous resistance monitoring are warranted for clinical practice guidance. Copyright (C) 2015, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
引用
收藏
页码:918 / 923
页数:6
相关论文
共 26 条
  • [1] [Anonymous], M02A11 CLSI
  • [2] [Anonymous], 2012, METH DIL ANT SUSC TE
  • [3] Clinical Characteristics and Risk Factors for Fatality in Patients with Bloodstream Infections Caused by Glucose Non-fermenting Gram-negative Bacilli
    Chang, Tzu-Yao
    Lee, Chen-Hsiang
    Liu, Jien-Wei
    [J]. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2010, 43 (03) : 233 - 239
  • [4] Clinical impact of Gram-negative nonfermenters on adults with community-onset bacteremia in the emergency department
    Chiu, Chun-Wei
    Li, Ming-Chi
    Ko, Wen-Chien
    Li, Chia-Wen
    Chen, Po-Lin
    Chang, Chia-Ming
    Lee, Nan-Yao
    Lee, Ching-Chi
    [J]. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2015, 48 (01) : 92 - 100
  • [5] Molecular epidemiology, antimicrobial susceptibility and carbapenemase resistance determinants among Acinetobacter baumannii clinical isolates in Taiwan
    Chuang, Yu-Chung
    Sheng, Wang-Huei
    Lauderdale, Tsai-Ling
    Li, Shu-Yin
    Wang, Jann-Tay
    Chen, Yee-Chun
    Chang, Shan-Chwen
    [J]. JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2014, 47 (04) : 324 - 332
  • [6] Influence of Genospecies of Acinetobacter baumannii Complex on Clinical Outcomes of Patients with Acinetobacter Bacteremia
    Chuang, Yu-Chung
    Sheng, Wang-Huei
    Li, Shu-Ying
    Lin, Yu-Chi
    Wang, Jann-Tay
    Chen, Yee-Chun
    Chang, Shan-Chwen
    [J]. CLINICAL INFECTIOUS DISEASES, 2011, 52 (03) : 352 - 360
  • [7] High prevalence of metallo-β-lactamase and 16S rRNA methylase coproduction among imipenem-resistant Pseudomonas aeruginosa isolates in Brazil
    Doi, Yohei
    Ghilardi, Angela C. R.
    Adams, Jennifer
    Garcia, Doroti de Oliveira
    Paterson, David L.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (09) : 3388 - 3390
  • [8] Non-fermentative Gram-negative bacteria
    Enoch, D. A.
    Birkett, C. I.
    Ludlam, H. A.
    [J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2007, 29 : S33 - S41
  • [9] RELIABILITY OF PHENOTYPIC TESTS FOR IDENTIFICATION OF ACINETOBACTER SPECIES
    GERNERSMIDT, P
    TJERNBERG, I
    URSING, J
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (02) : 277 - 282
  • [10] Emergence of 16S rRNA methylase gene armA and cocarriage of blaIMP-1 in Pseudomonas aeruginosa isolates from South Korea
    Gurung, Mamata
    Moon, Dong Chan
    Tamang, Migma Dorji
    Kim, Jung
    Lee, Yoo Chul
    Seol, Sung Yong
    Cho, Dong Taek
    Lee, Je Chul
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2010, 68 (04) : 468 - 470