Resorbable composites with bioresorbable glass fibers for load-bearing applications. In vitro degradation and degradation mechanism

被引：45

作者：

Lehtonen, Timo J. ^{[1
]}

Tuominen, Jukka U. ^{[1
]}

Hiekkanen, Elina ^{[1
]}

机构：

[1] Vivoxid Ltd, FI-20750 Turku, Finland

来源：

ACTA BIOMATERIALIA | 2013年 / 9卷 / 01期

关键词：

In vitro degradation; Bioresorbable; Glass fibers; Composite; Mechanical properties; STRUCTURE-PROPERTY RELATIONSHIPS; MASSIVE POLY(ALPHA-HYDROXY ACIDS); POLY-L-LACTIDE; HYDROLYTIC DEGRADATION; AQUEOUS-MEDIA; BIODEGRADABLE POLYMERS; ALIPHATIC POLYESTERS; TRICALCIUM PHOSPHATE; BLOCK POLYESTER; MORPHOLOGY;

D O I：

10.1016/j.actbio.2012.08.052

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An in vitro degradation study of three bioresorbable glass fiber-reinforced poly(L-lactide-co-DL-lactide) (PLDLA) composites was carried out in simulated body fluid (SBF), to simulate body conditions, and deionized water, to evaluate the nature of the degradation products. The changes in mechanical and chemical properties were systematically characterized over 52 weeks dissolution time to determine the degradation mechanism and investigate strength retention by the bioresorbable glass fiber-reinforced PLDLA composite. The degradation mechanism was found to be a combination of surface and bulk erosion and does not follow the typical core-accelerated degradation mechanism of poly(alpha-hydroxyacids). Strength retention by bioresorbable glass fiber-reinforced PLDLA composites can be tailored by changing the oxide composition of the glass fibers, but the structure-property relationship of the glass fibers has to be understood and controlled so that the phenomenon of ion leaching can be utilized to control the degradation rate. Therefore, these high performance composites are likely to open up several new possibilities for utilizing resorbable materials in clinical applications which could not be realized in the past. (C) 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：4868 / 4877

页数：10

共 47 条

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