Advances in crosslinking strategies of biomedical hydrogels

被引：647

作者：

Hu, Weikang ^{[1
,2
]}

Wang, Zijian ^{[3
,4
]}

Xiao, Yu ^{[3
,4
]}

Zhang, Shengmin ^{[1
]}

Wang, Jianglin ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Adv Biomat & Tissue Engn Ctr, Wuhan 430074, Hubei, Peoples R China

[2] Wuhan Inst Biotechnol, Wuhan 430075, Hubei, Peoples R China

[3] Wuhan Univ, Zhongnan Hosp, Dept Urol, Wuhan 430071, Hubei, Peoples R China

[4] Wuhan Univ, Zhongnan Hosp, Dept Biol Repositories, Wuhan 430071, Hubei, Peoples R China

来源：

BIOMATERIALS SCIENCE | 2019年 / 7卷 / 03期

基金：

中国国家自然科学基金;

关键词：

CHITOSAN-BASED HYDROGELS; ACID-BASED HYDROGELS; BIPYRIDYL-BRANCHED POLYOXAZOLINE; CELL-ENCAPSULATING HYDROGELS; TERPYRIDINE METAL-COMPLEXES; SELF-HEALING HYDROGELS; GROWTH-FACTOR DELIVERY; HYALURONIC-ACID; ALPHA-CYCLODEXTRIN; EXTRACELLULAR-MATRIX;

D O I：

10.1039/c8bm01246f

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Biomedical hydrogels as sole repair matrices or combined with pre-seeded cells and bioactive growth factors are extensively applied in tissue engineering and regenerative medicine. Hydrogels normally provide three dimensional structures for cell adhesion and proliferation or the controlled release of the loading of drugs or proteins. Various physiochemical properties of hydrogels endow them with distinct applications. In this review, we present the commonly used crosslinking method for hydrogel synthesis involving physical and chemical crosslinks and summarize their current progress and future perspectives.

引用

页码：843 / 855

页数：13

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