Neural control of the gastrointestinal tract: Implications for Parkinson disease

被引：135

作者：

Cersosimo, Maria G. ^{[2
]}

Benarroch, Eduardo E. ^{[1
]}

机构：

[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[2] Univ Buenos Aires, Hosp Clin, Parkinsons Dis & Movement Disorder Unit, RA-1053 Buenos Aires, DF, Argentina

来源：

MOVEMENT DISORDERS | 2008年 / 23卷 / 08期

关键词：

vagal nuclei; enteric nervous system; dysphagia; constipation; Lewy bodies;

D O I：

10.1002/mds.22051

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Disorders of swallowing and gastrointestinal motility are prominent nonmotor manifestations of Parkinson disease (PD). Motility of the gut is controlled both by extrinsic inputs from the dorsal motor nucleus of the vagus (DMV) and paravertebral sympathetic ganglia and by local reflexes mediated by intrinsic neurons of the enteric nervous system (ENS). Both the ENS and the DMV are affected by Lewy body pathology at early stages of PD. This early involvement provides insights into the pathophysiology of gastrointestinal dysmotility in this disorder and may constitute an important step in the etiopathogenesis of Lewy body disease. (C) 2008 Movement Disorder Society.

引用

页码：1065 / 1075

页数：11

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