Recent Developments in G-Quadruplex Probes

被引：161
作者：
Ma, Dik-Lung [1 ,2 ]
Zhang, Zhihong [1 ]
Wang, Modi [1 ]
Lu, Lihua [1 ]
Zhong, Hai-Jing [3 ]
Leung, Chung-Hang [3 ]
机构：
[1] Hong Kong Baptist Univ, Dept Chem, Kowloon, Hong Kong, Peoples R China
[2] Hong Kong Baptist Univ, Partner State Key Lab Environm & Biol Anal, Kowloon, Hong Kong, Peoples R China
[3] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
来源：
CHEMISTRY & BIOLOGY | 2015年 / 22卷 / 07期
关键词：
SWITCH-ON PROBE; INTRAMOLECULAR G-QUADRUPLEX; TELOMERIC G-QUADRUPLEX; MOLECULAR LIGHT SWITCH; LABEL-FREE DETECTION; SELECTIVE DETECTION; FLUORESCENT-PROBE; DISPLACEMENT ASSAY; SENSING PLATFORM; THIAZOLE ORANGE;
D O I：
10.1016/j.chembiol.2015.06.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Accumulating evidence has linked G-quadruplex structures to a number of biological processes in vivo, including DNA replication, transcription, and genomic maintenance. However, the precise function and mechanism of G-quadruplex formation in mammalian cells remains poorly defined. Therefore, the development of small-molecule G-quadruplex probes has attracted significant attention in recent years. This review highlights examples of G-quadruplex probes that have been reported over the last few years, some of which have been employed for cellular imaging or for use in the construction of G-quadruplex-based analytical sensing platforms.
引用
收藏
页码：812 / 828
页数：17
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