What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? Rigorous Simian Immunodeficiency Virus Vaccine Trials Can Be Instructive

被引：13

作者：

Martins, Mauricio A. ^{[1
]}

Watkins, David I. ^{[1
]}

机构：

[1] Univ Miami, Dept Pathol, Miami, FL 33136 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2018年 / 10卷 / 04期

关键词：

HIGHLY PATHOGENIC SIV; HIV-1; VACCINE; DOUBLE-BLIND; ZIKA VIRUS; NEUTRALIZING ANTIBODIES; GAG/POL/NEF VACCINE; DISEASE PROGRESSION; PROTECTIVE EFFICACY; RHESUS MACAQUES; REPLICATION;

D O I：

10.1101/cshperspect.a029504

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Simian immunodeficiency virus (SIV) challenge of rhesus macaques provides an invaluable tool to evaluate the clinical prospects of HIV-1 vaccine concepts. However, as with any animal model of human disease, it is crucial to understand the advantages and limitations of this system to maximize the translational value of SIV vaccine studies. Here, we discuss the importance of assessing the efficacy of vaccine prototypes using stringent SIV challenge regimens that mimic HIV-1 transmission and pathogenesis. We also review some of the cautionary tales of HIV-1 vaccine research because they provide general lessons for the preclinical assessment of vaccine candidates.

引用

页数：10

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