The Chemical Syntheses of Nannocystins

被引：6
|
作者：
Wang, Zhang [1 ]
机构：
[1] SUNY Albany, 1400 Washington Ave, Albany, NY 12222 USA
来源：
SYNTHESIS-STUTTGART | 2019年 / 51卷 / 11期
关键词：
nannocystin; total synthesis; depsipeptide; SAR studies; elongation factor inhibitor; BIOLOGICAL EVALUATION; ELONGATION-FACTORS; OLEFIN METATHESIS; ANALOGS;
D O I：
10.1055/s-0037-1611796
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The broad and potent anticancer activity of the nannocystin family of natural products has attracted significant efforts toward their total syntheses. Currently, seven total syntheses of different members of the nannocystins have been reported. In this Short Review, different synthetic approaches are highlighted. The reported structure-activity relationship (SAR) studies will also be highlighted.
引用
收藏
页码：2252 / 2260
页数：9
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