Cushing's disease in a 7-month-old girl due to a tumor producing adrenocorticotropic hormone and thyreotropin-secreting hormone

被引：9

作者：

List, JV ^{[1
]}

Sobottka, S ^{[1
]}

Huebner, A ^{[1
]}

Bonk, C ^{[1
]}

Koy, J ^{[1
]}

Pinzer, T ^{[1
]}

Schackert, G ^{[1
]}

机构：

[1] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Neurosurg, D-01307 Dresden, Germany

来源：

PEDIATRIC NEUROSURGERY | 1999年 / 31卷 / 01期

关键词：

pituitary adenoma; adrenocorticotropic hormone; thyreotropin-secreting hormone; Cushing's disease; Cushing's syndrome; neurosurgery;

D O I：

10.1159/000028824

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We present the case of a 7-month-old baby with Cushing's disease due to an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma combined with cells producing thyreotropin-secreting hormone (TSH). In MRI scans, a contrast-enhancing lesion was seen inside the pituitary fossa, and it extended into the suprasellar region. On the assumption of a pituitary adenoma, surgery was performed. Corresponding with biochemical findings, histopathological evaluation revealed an ACTH- and TSH-producing tumor. Genetic analysis did not demonstrate an alteration at codon 201 (Arg) and 227 (Glu). To our knowledge, th is is the fi rst case described in a child of this age.

引用

页码：7 / 11

页数：5

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