MicroRNAs Are Key Molecules Involved in the Gene Regulation Network of Colorectal Cancer

被引：8

作者：

Yang, Fangfang ^{[1
,2
]}

Xuan, Guoyun ^{[3
]}

Chen, Yixin ^{[1
,2
]}

Cao, Lichao ^{[1
,2
]}

Zhao, Min ^{[1
,2
]}

Wang, Chen ^{[1
,2
]}

Chen, Erfei ^{[1
,2
]}

机构：

[1] Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Xian, Peoples R China

[2] Northwest Univ, Prov Key Lab Biotechnol Shaanxi Prov, Xian, Peoples R China

[3] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Natl Clin Res Ctr Digest Dis, State Key Lab Canc Biol, Xian, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

关键词：

colorectal cancer; miRNA; biomarker; gene regulation; signaling pathway; EPITHELIAL-MESENCHYMAL TRANSITION; PROMOTES TUMOR-GROWTH; COLON-CANCER; SIGNALING PATHWAYS; CELL-PROLIFERATION; PLASMA MICRORNAS; MIR-200; FAMILY; FEEDBACK LOOP; DISTANT METASTASIS; CATENIN PATHWAY;

D O I：

10.3389/fcell.2022.828128

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Colorectal cancer (CRC) is one of the most common types of cancer and one of the leading causes of mortality worldwide. MicroRNAs (miRNAs) play central roles in normal cell maintenance, development, and other physiological processes. Growing evidence has illustrated that dysregulated miRNAs can participate in the initiation, progression, metastasis, and therapeutic resistance that confer miRNAs to serve as clinical biomarkers and therapeutic targets for CRC. Through binding to the 3 '-untranslated region (3 '-UTR) of target genes, miRNAs can lead to target mRNA degradation or inhibition at a post-transcriptional level. During the last decade, studies have found numerous miRNAs and their potential targets, but the complex network of miRNA/Targets in CRC remains unclear. In this review, we sought to summarize the complicated roles of the miRNA-target regulation network (Wnt, TGF-beta, PI3K-AKT, MAPK, and EMT related pathways) in CRC with up-to-date, high-quality published data. In particular, we aimed to discuss the downstream miRNAs of specific pathways. We hope these data can be a potent supplement for the canonical miRNA-target regulation network.

引用

页数：13

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