Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists

被引：38

作者：

Di Fabio, R ^{[1
]}

Giovannini, R ^{[1
]}

Bertani, B ^{[1
]}

Borriello, M ^{[1
]}

Bozzoli, A ^{[1
]}

Donati, D ^{[1
]}

Falchi, A ^{[1
]}

Ghirlanda, D ^{[1
]}

Leslie, CP ^{[1
]}

Pecunioso, A ^{[1
]}

Rumboldt, G ^{[1
]}

Spada, S ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Med Res Ctr, I-37135 Verona, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 06期

关键词：

NPY-1; antagonists; GPCR;

D O I：

10.1016/j.bmcl.2005.11.104

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The SAR of a new series of tetrahydrocarbazole derivatives is described: the appropriate decoration of this template led to the identification of a new class of NPY-1 antagonists showing good in vitro potency and a promising in vivo pharmacokinetic profile in rat. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1749 / 1752

页数：4

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