Bcl-2 inhibits p53 nuclear import following DNA damage

被引:82
作者
Beham, A
Marin, MC
Fernandez, A
Herrmann, J
Brisbay, S
Tari, AM
LopezBerestein, G
Lozano, G
Sarkiss, M
McDonnell, TJ
机构
[1] UNIV TEXAS,MD ANDERSON CANCER CTR,DIV MOL PATHOL,HOUSTON,TX 77030
[2] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT IMMUNOBIOL & DRUG CARRIERS,HOUSTON,TX 77030
[3] UNIV TEXAS,MD ANDERSON CANCER CTR,DEPT MOL GENET,HOUSTON,TX 77030
关键词
apoptosis; bcl-2; nuclear import; p53; prostate cancer;
D O I
10.1038/sj.onc.1201464
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Bcl-2 is an integral membrane oncoprotein that localizes to membranes of the mitochondria, endoplasmic reticulum, and nuclear envelope, Bcl-2 is a member of a family of cell death regulators and functions to inhibit apoptosis, Using confocal microscopy and immunoblotting we show that the ability of bcl-2 to suppress cell death following genotoxic damage can be a consequence of inhibiting nuclear import of induced wild-type p53 protein, Our data suggests that the ability of bcl-2 to modulate trafficking events is not cell type specific, These data support a 'gatekeeper' mechanism for cell death suppression by bcl-2.
引用
收藏
页码:2767 / 2772
页数:6
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