Polyethylene glycol (PEG-400): An efficient one-pot green synthesis and anti-viral activity of novel α-diaminophosphonates

被引：10

作者：

Patnala, Harika ^{[1
]}

Abbo, Hanna S. ^{[2
,3
]}

Potla, Krishna Murthy ^{[4
]}

Titinchi, Salam J. J. ^{[2
,3
]}

Chinnam, Sampath ^{[5
]}

机构：

[1] Andhra Loyola Inst Engn & Technol, Dept Chem, Vijayawada, Andhra Pradesh, India

[2] Univ Basrah, Dept Chem, Basrah, Iraq

[3] Univ Western Cape, Dept Chem, Cape Town, South Africa

[4] Acharya Nagarjuna Univ, Post Grad Res Ctr, Bapatla Engn Coll, Dept Chem, Bapatla, Andhra Pradesh, India

[5] BMS Coll Engn, Dept Chem, Bengaluru, Karnataka, India

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2019年 / 194卷 / 11期

关键词：

Green synthesis; alpha-diaminophosphonates; anti-viral activity; Kabachnik-Fields reaction; AMINO-PHOSPHONATES; 3-COMPONENT SYNTHESIS; ACID-DERIVATIVES; CATALYST; SOLVENT; AMINOPHOSPHONATES; INHIBITION; CHLORIDE; FACILE; KETONES;

D O I：

10.1080/10426507.2019.1597365

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

An efficient and eco-friendly protocol has been accomplished for a series of novel alpha-diaminophosphonates by a one-pot, three-component system via Kabachnik-Fields reaction of 4,4 '-methylenedianiline, a variety of aryl/heteroaryl aldehydes and diphenylphosphite employing polyethylene glycol (PEG-400) as a green solvent at 80 degrees C. All products were obtained in good to excellent yields (80-95%). The identity of the new synthesized compounds was confirmed by IR, H-1, 13C, and 31P NMR, LC-MS and elemental analysis. In vivo anti-viral activity was evaluated against tobacco mosaic virus (TMV). Compounds 4b, 4c, 4j and 4k exhibited the highest anti-viral activities against tobacco mosaic virus (TMV) when compared with the standard drug ningnanmycin. [GRAPHICS] .

引用

页码：1035 / 1039

页数：5

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