Direct and label-free detection of the human growth hormone in urine by an ultrasensitive bimodal waveguide biosensor

被引：41
|
作者：
Belen Gonzalez-Guerrero, Ana
Maldonado, Jesus
Dante, Stefania
Grajales, Daniel
Lechuga, Laura M. [1 ]
机构：
[1] CSIC, Catalan Inst Nanosci & Nanotechnol ICN2, Nanobiosensors & Bioanalyt Applicat Grp, CIBER BBN, Campus UAB, Barcelona 08193, Spain
来源：
JOURNAL OF BIOPHOTONICS | 2017年 / 10卷 / 01期
关键词：
BiMW interferometer; silicon nanowaveguides; label-free biosensing; hGH detection; pg/mL detection range; IMMUNOASSAYS; SENSOR; HGH;
D O I：
10.1002/jbio.201600154
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A label-free interferometric transducer showing a theoretical detection limit for homogeneous sensing of 5 x 10(-8) RIU, being equivalent to a protein mass coverage resolution of 2.8 fg mm(-2), is used to develop a high sensitive biosensor for protein detection. The extreme sensitivity of this transducer combined with a selective bioreceptor layer enables the direct evaluation of the human growth hormone (hGH) in undiluted urine matrix in the 10 pg mL(-1) range.
引用
收藏
页码：61 / 67
页数：7
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