Do sirtuins promote mammalian longevity?: A Critical review on its relevance to the longevity effect induced by calorie restriction

被引：55
作者：
Park, Seongjoon [1 ]
Mori, Ryoichi [1 ]
Shimokawa, Isao [1 ]
机构：
[1] Nagasaki Univ, Grad Sch Biomed Sci, Dept Invest Pathol, Unit Basic Med Sci, Nagasaki 8528523, Japan
来源：
MOLECULES AND CELLS | 2013年 / 35卷 / 06期
基金：
日本学术振兴会;
关键词：
calorie restriction; longevity; metabolism; sirtuins; FATTY-ACID OXIDATION; DEPENDENT GENE-EXPRESSION; LIFE-SPAN EXTENSION; SACCHAROMYCES-CEREVISIAE; DIETARY RESTRICTION; CELL-SURVIVAL; MITOCHONDRIAL-FUNCTION; GLUCOSE-HOMEOSTASIS; INSULIN-SECRETION; ACTIVATING SIRT1;
D O I：
10.1007/s10059-013-0130-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sirtuins (SIRTs), a family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, are emerging as key molecules that regulate aging and age-related diseases including cancers, metabolic disorders, and neurodegenerative diseases. Seven isoforms of SIRT (SIRT1-7) have been identified in mammals. SIRT1 and 6, mainly localized in the nucleus, regulate transcription of genes and DNA repair. SIRT3 in the mitochondria regulates mitochondrial bioenergetics. Initial studies in yeasts, nematodes, and flies indicated a strong connection of SIRT with the life-prolonging effects of calorie restriction (CR), a robust experimental intervention for longevity in a range of organisms. However, subsequent studies reported controversial findings regarding SIRT roles in the effect of CR. This review describes the functional roles of mammalian SIRTs and discusses their relevance to mechanisms underlying the longevity effect of CR.
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收藏
页码：474 / 480
页数：7
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