Chlamydial Intracellular Survival Strategies

被引：175

作者：

Bastidas, Robert J. ^{[1
]}

Elwell, Cherilyn A. ^{[2
]}

Engel, Joanne N. ^{[2
,3
]}

Valdivia, Raphael H. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Ctr Microbial Pathogenesis, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2013年 / 3卷 / 05期

基金：

美国国家卫生研究院;

关键词：

TOLL-LIKE RECEPTOR-2; ENDOCYTIC MULTIVESICULAR BODIES; TRACHOMATIS INCLUSION MEMBRANE; NUCLEOTIDE EXCHANGE FACTOR; ADP-RIBOSYLATION FACTORS; BLOOD MONONUCLEAR-CELLS; KAPPA-B PATHWAY; EPITHELIAL-CELLS; GENITAL-TRACT; INTERFERON-GAMMA;

D O I：

10.1101/cshperspect.a010256

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen and the causative agent of blinding trachoma. Although Chlamydia is protected from humoral immune responses by residing within remodeled intracellular vacuoles, it still must contend with multilayered intracellular innate immune defenses deployed by its host while scavenging for nutrients. Here we provide an overview of Chlamydia biology and highlight recent findings detailing how this vacuole-bound pathogen manipulates host-cellular functions to invade host cells and maintain a replicative niche.

引用

页数：20

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