Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

被引：263

作者：

Ansari, Aneesa ^{[1
]}

Rahman, Md. Shahedur ^{[1
]}

Saha, Subbroto K. ^{[2
]}

Saikot, Forhad K. ^{[1
]}

Deep, Akash ^{[3
]}

Kim, Ki-Hyun ^{[4
]}

机构：

[1] Jessore Univ Sci & Technol, Dept Genet Engn & Biotechnol, Jessore 7408, Bangladesh

[2] Konkuk Univ, Dept Stem Cell & Regenerat Biol, 120 Neungdong Ro, Seoul 05029, South Korea

[3] CSIR, CSIO, Sect 30 C, Chandigarh 160030, India

[4] Hanyang Univ, Dept Civil & Environm Engn, 222 Wangsimni Ro, Seoul 04763, South Korea

来源：

AGING CELL | 2017年 / 16卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

aging; cancer; Silent Information Regulator 2; SIRT3; sirtuin; MANGANESE SUPEROXIDE-DISMUTASE; STRESS-RESPONSIVE DEACETYLASE; OXIDATIVE STRESS; TUMOR-SUPPRESSOR; HEPATOCELLULAR-CARCINOMA; PROTEIN DEACETYLASE; SIRT3-MEDIATED DEACETYLATION; CALORIE RESTRICTION; ENERGY-METABOLISM; NAD(+) DEPLETION;

D O I：

10.1111/acel.12538

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In mammals, seven members of the sirtuin protein family known as class III histone deacetylase have been identified for their characteristic features. These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involvement in diseases. Among the sirtuin members, SIRT3 has received much attention for its role in cancer genetics, aging, neurodegenerative disease, and stress resistance. SIRT3 controls energy demand during stress conditions such as fasting and exercise as well as metabolism through the deacetylation and acetylation of mitochondrial enzymes. SIRT3 is well known for its ability to eliminate reactive oxygen species and to prevent the development of cancerous cells or apoptosis. This review article provides a comprehensive review on numerous (noteworthy) molecular functions of SIRT3 and its effect on cancer cells and various diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease.

引用

页码：4 / 16

页数：13

共 130 条

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