The effect of high-dose inhaled budesonide on lipid profile in asthmatic patients

被引：5
|
作者：
Yavuz, O
Turktas, I
Cevik, C
机构：
[1] GAZI UNIV HOSP,DEPT PAEDIAT ALLERGY,ANKARA,TURKEY
[2] GAZI UNIV HOSP,FAC MED,ANKARA,TURKEY
来源：
GENERAL PHARMACOLOGY | 1996年 / 27卷 / 01期
关键词：
D O I：
10.1016/0306-3623(95)00119-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1. We determined the effect of high doses of inhaled corticosteroid (budesonide, BUD, 1600 mu g/day for 4 weeks) on fasting triglyceride, cholesterol and high density lipoprotein (HDL)-cholesterol concentration in 11 asthmatic patients. 2. No significant change of serum fasting triglyceride concentrations was found before and after BUD therapy (p>0.05). However, serum fasting cholesterol concentrations decreased slightly (p=0.03) and HDL-cholesterol concentrations increased after BUD therapy for four weeks (p=0.01). 3. These results suggest that high-dose BUD therapy does have minor effects on lipid metabolism after long periods of use in asthmatic patients.
引用
收藏
页码：89 / 90
页数：2
相关论文
共 50 条
  • [1] EFFECT OF MEDIUM AND HIGH DOSE INHALED BUDESONIDE ON BONE DENSITY IN ASTHMATIC PATIENTS
    Karadag, Fisun
    Cam, Murat
    Yurekli, Yakup
    Cildag, Orhan
    EURASIAN JOURNAL OF PULMONOLOGY, 2005, 7 (01) : 1 - 6
  • [2] ADVANTAGES OF HIGH-DOSE INHALED BUDESONIDE
    ADELROTH, E
    THOMPSON, S
    LANCET, 1988, 1 (8583): : 476 - 476
  • [3] High-dose inhaled steroids in asthmatic children
    Lipworth, BJ
    Clark, D
    LANCET, 1996, 348 (9030): : 820 - 820
  • [4] EFFECT OF HIGH-DOSE INHALED STEROID-THERAPY ON BONE IN ASTHMATIC-PATIENTS
    HANANIA, NA
    CHAPMAN, KR
    STURTRIDGE, WC
    KESTEN, S
    CALCIFIED TISSUE INTERNATIONAL, 1994, 54 (04) : 353 - 353
  • [5] INHALED SALMETEROL AND ALBUTEROL IN ASTHMATIC-PATIENTS RECEIVING HIGH-DOSE INHALED CORTICOSTEROIDS
    LAI, CKW
    CHAN, CHS
    HO, SS
    HUI, ACF
    LAI, KN
    CHEST, 1995, 108 (01) : 36 - 40
  • [6] A comparison of low-dose inhaled budesonide plus theophylline and high-dose inhaled budesonide for moderate asthma
    Evans, DJ
    Taylor, DA
    Zetterstrom, O
    Chung, F
    OConnor, BJ
    Barnes, PJ
    NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (20): : 1412 - 1418
  • [7] High-dose inhaled steroids in asthmatic children - Reply
    Todd, G
    Shields, MD
    Carson, D
    LANCET, 1996, 348 (9030): : 821 - 821
  • [8] Deteriorating diabetic control associated with high-dose inhaled budesonide
    Faul, JL
    Cormican, LJ
    Tormey, VJ
    Tormey, WP
    Burke, CM
    EUROPEAN RESPIRATORY JOURNAL, 1999, 14 (01) : 242 - 243
  • [9] EFFECT OF HIGH-DOSE INHALED BUDESONIDE ON CALCIUM AND PHOSPHATE-METABOLISM AND THE RISK OF OSTEOPOROSIS
    TOOGOOD, JH
    CRILLY, RG
    JONES, G
    NADEAU, J
    WELLS, GA
    AMERICAN REVIEW OF RESPIRATORY DISEASE, 1988, 138 (01): : 57 - 61
  • [10] HIGH-DOSE INHALED BUDESONIDE GIVEN AFTER ALLERGEN INHALATION REDUCES THE SEVERITY OF THE LATE RESPONSE TO THE ALLERGEN IN ASTHMATIC SUBJECTS
    PAGGIARO, PL
    MORELLI, MC
    BANCALARI, L
    DENTE, FL
    DIFRANCO, A
    GIANNINI, D
    FABBRI, LM
    GIUNTINI, C
    AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (04): : A25 - A25
12345