Expression of cycloxygenase-2 in astrocytes of human brain after global ischemia

被引:0
|
作者
Maslinska, D
Wozniak, R
Kaliszek, A
Modelska, I
机构
[1] Polish Acad Sci, Med Res Ctr, Dept Dev Neuropathol, PL-02106 Warsaw, Poland
[2] Med Acad, Dept Pathophysiol, Warsaw, Poland
来源
FOLIA NEUROPATHOLOGICA | 1999年 / 37卷 / 02期
关键词
COX-2; astrocytes; brain; human; ischemia;
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
COX-2 expression, an inducible form of cyclooxygenase was studied in human brain after ischemia-reperfusion. Previously, a prominent COX-2 upregulation was described in neurons few hours or days after ischemia but little is known about COX-2 expression in non-neuronal cells participating in post-ischemic inflammation. Aim of the study was to examine COX-2 expression in activated glial cells of individuals, who died two or more weeks after resuscitation. In the cerebral cortex of these individuals ischemic necrosis was more or less widespread. In some brain areas numerous microglial cells were found. At the centre of the necrosis high expression of COX-2 was detected in macrophages, polymorphic cells and leukocytes. At the margin of necrosis hypertrophic astrocytes were COX-2 immunopositive. Expression of COX-2 was observed also in the wall of blood vessels of necrotic brain areas and in meninges. The results of the study suggest that in the late period after global ischemia reactive and hypertrophic astrocytes and macrophages may be the major sources of prostaglandins in the human brain.
引用
收藏
页码:75 / 79
页数:5
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