The ApoE e4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors?

被引：21

作者：

Bos, Maxime M. ^{[1
]}

Noordam, Raymond ^{[1
]}

Blauw, Gerard J. ^{[1
]}

Slagboom, P. Eline ^{[2
]}

Rensen, Patrick C. N. ^{[3
,4
]}

van Heemst, Diana ^{[1
]}

机构：

[1] Leiden Univ, Med Ctr, Sect Gerontol & Geriatr, Dept Internal Med, POB 9600, NL-2300 RC Leiden, Netherlands

[2] Leiden Univ, Med Ctr, Dept Med Stat & Bioinformat, Sect Mol Epidemiol, Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Div Endocrinol, Dept Med, Leiden, Netherlands

[4] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2019年 / 74卷 / 01期

关键词：

Apolipoprotein(s); Dyslipidemias; Genetics; Lipoproteins; metabolism; Omega-3 fatty acids; Alzheimers disease; Exercise; APOLIPOPROTEIN-E GENOTYPE; CYSTEINE-ARGININE INTERCHANGE; LIPOPROTEIN RECEPTOR-BINDING; LIFE-STYLE INTERVENTION; MEDITERRANEAN DIET; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY; COGNITIVE DECLINE; E POLYMORPHISM; REPLACEMENT MICE;

D O I：

10.1093/gerona/gly226

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Candidate gene studies and genome-wide association studies found that genetic variation in APOE is robustly associated with multiple age-related diseases and longevity. Apolipoprotein E (ApoE) is an apolipoprotein that plays an important role in triglyceride and cholesterol metabolism. In literature, especially the ApoE ?4 isoform has been associated with an increased risk of mortality and age-related diseases such as Alzheimers disease (AD), cardiovascular diseases (CVD), as compared to the neutral ApoE ?3 isoform. There are, however, large differences in the deleterious effects of the ApoE ?4 isoform between ancestries and populations, which might be explained by differences in environmental and lifestyle exposures. In this respect, poor nutrition and physical inactivity are two important lifestyle factors that have been associated with increased risks for AD and CVD. Therefore, in this narrative review, we discuss how omega-3 fatty acid intake and physical activity may modify the impact of ApoE ?4 on AD and CVD risk.

引用

页码：99 / 107

页数：9

共 98 条

[1] Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism [J].