Molecular mechanisms of bitter and sweet taste transduction

被引：326
作者：
Margolskee, RF [1 ]
机构：
[1] CUNY Mt Sinai Sch Med, Howard Hughes Med Inst, Dept Physiol & Biophys, New York, NY 10029 USA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 2002年 / 277卷 / 01期
关键词：
D O I：
10.1074/jbc.R100054200
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页码：1 / 4
页数：4
相关论文
共 48 条
[21]   A CYCLIC-NUCLEOTIDE-SUPPRESSIBLE CONDUCTANCE ACTIVATED BY TRANSDUCIN IN TASTE CELLS [J].
KOLESNIKOV, SS ;
MARGOLSKEE, RF .
NATURE, 1995, 376 (6535) :85-88
[22]   Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor [J].
Kunishima, N ;
Shimada, Y ;
Tsuji, Y ;
Sato, T ;
Yamamoto, M ;
Kumasaka, T ;
Nakanishi, S ;
Jingami, H ;
Morikawa, K .
NATURE, 2000, 407 (6807) :971-977
[23]   Identification of two α-subunit species of GTP-binding proteins, Gα15 and Gαq, expressed in rat taste buds [J].
Kusakabe, Y ;
Yamaguchi, E ;
Tanemura, K ;
Kameyama, K ;
Chiba, N ;
Arai, S ;
Emori, Y ;
Abe, K .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1998, 1403 (03) :265-272
[24]   High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4 [J].
Li, X ;
Inoue, M ;
Reed, DR ;
Huque, T ;
Puchalski, RB ;
Tordoff, MG ;
Ninomiya, Y ;
Beauchamp, GK ;
Bachmanov, AA .
MAMMALIAN GENOME, 2001, 12 (01) :13-16
[25]   THE GENETICS OF TASTING IN MICE .6. SACCHARIN, ACESULFAME, DULCIN AND SUCROSE [J].
LUSH, IE .
GENETICS RESEARCH, 1989, 53 (02) :95-99
[26]   THE GENETICS OF TASTING IN MICE .7. GLYCINE REVISITED, AND THE CHROMOSOMAL LOCATION OF SAC AND SOA [J].
LUSH, IE ;
HORNIGOLD, N ;
KING, P ;
STOYE, JP .
GENETICAL RESEARCH, 1995, 66 (02) :167-174
[27]   A family of candidate taste receptors in human and mouse [J].
Matsunami, H ;
Montmayeur, JP ;
Buck, LB .
NATURE, 2000, 404 (6778) :601-+
[28]   Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac [J].
Max, M ;
Shanker, YG ;
Huang, LQ ;
Rong, M ;
Liu, Z ;
Campagne, F ;
Weinstein, H ;
Damak, S ;
Margolskee, RF .
NATURE GENETICS, 2001, 28 (01) :58-63
[29]   GUSTDUCIN IS A TASTE-CELL-SPECIFIC G-PROTEIN CLOSELY RELATED TO THE TRANSDUCINS [J].
MCLAUGHLIN, SK ;
MCKINNON, PJ ;
MARGOLSKEE, RF .
NATURE, 1992, 357 (6379) :563-569
[30]   Characterization and solubilization of bitter-responsive receptors that couple to gustducin [J].
Ming, D ;
Ruiz-Avila, L ;
Margolskee, RF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8933-8938
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