Distinguishing pancreatic cancer from chronic pancreatitis and healthy individuals by 1H nuclear magnetic resonance-based metabonomic profiles

被引：79

作者：

Zhang, Lin ^{[1
]}

Jin, Haifeng ^{[1
]}

Guo, Xuegang ^{[1
]}

Yang, Zhao ^{[1
]}

Zhao, Lina ^{[1
]}

Tang, Shanhong ^{[1
]}

Mo, Ping ^{[1
]}

Wu, Kaichun ^{[1
]}

Nie, Yongzhan ^{[1
]}

Pan, Yanglin ^{[1
]}

Fan, Daiming ^{[1
]}

机构：

[1] Fourth Mil Med Univ, State Key Lab Canc Biol, Xijing Hosp Digest Dis, Xian 710032, Shaanxi, Peoples R China

来源：

CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 13-14期

基金：

中国国家自然科学基金;

关键词：

NMR; Metabonomics; Pancreatic cancer; Chronic pancreatitis; Biomarker; HDL CHOLESTEROL; SPECTROSCOPY; CARCINOMA; DIAGNOSIS; DISEASE; LIPIDS; SERUM; RISK;

D O I：

10.1016/j.clinbiochem.2012.05.012

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: To develop a noninvasive and accessible diagnostic method for pancreatic cancer (PC). Design and methods: We presented a metabolomic method, pattern recognition techniques applied to H-1 nuclear magnetic resonance (H-1 NMR) spectra, to investigate the plasma metabolites obtained from 19 patients with PC, 20 patients with chronic pancreatitis (CP) and 20 healthy individuals. Results: Metabolic changes associated with PC included abnormal amino acid and lipid metabolism, and possible multiple metabolic syndrome. PC elevated plasma levels of N-acetyl glycoprotein (NAG), dimethylamine (DMA), very low density lipoprotein (VLDL), and acetone, and reduced levels of 3-hydroxybutyrate, lactate, high density lipoprotein (HDL), low density lipoprotein (LDL), citrate, alanine, glutamate, glutamine, histidine, isoleucine, lysine, and valine. These metabolites could be a biomarker group for PC that distinguishes between PC and CP patients and healthy individuals. Conclusions: NMR-based metabonomic strategy appears as a promising approach for distinguishing pancreatic cancer and identifying new strategies for prevention or therapy in the clinical practice. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：1064 / 1069

页数：6

共 33 条

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