The Insulin-Like Growth Factor System in Cancer

被引：172

作者：

Weroha, S. John ^{[1
]}

Haluska, Paul ^{[1
]}

机构：

[1] Mayo Clin, Dept Oncol, Div Med Oncol, Coll Med, Rochester, MN 55905 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2012年 / 41卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Insulin-like growth factor; Cancer risk stratification; Growth hormone; Signal transduction; FACTOR-I-RECEPTOR; IGF BINDING PROTEIN-3; PHOSPHATIDYLINOSITOL 3-KINASE/AKT PATHWAY; OVARIAN-CARCINOMA CELLS; BREAST-CANCER; HYBRID RECEPTORS; LUNG-CANCER; FACTOR (IGF)-I; GLIOBLASTOMA CELLS; ANTITUMOR-ACTIVITY;

D O I：

10.1016/j.ecl.2012.04.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin-like growth factor (IGF) plays an important role in tissue growth and development. Several studies have demonstrated the association between circulating levels of IGF-1 and -2 and cancer risk, and the IGF system has been implicated in the oncogenesis of essentially all solid and hematologic malignancies. The optimal strategy for targeting IGF signaling in patients with cancer is not clear. The modest benefits reported thus far underscore the need for a better understanding of IGF signaling, which would enable clinicians to identify the subset of patients with the greatest likelihood of attaining benefit from this targeted approach.

引用

页码：335 / +

页数：17

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