Pituitary development: a complex, temporal regulated process dependent on specific transcriptional factors

被引：46
作者：
de Moraes, Debora Cristina [1 ]
Vaisman, Mario [2 ]
Conceicao, Flavia Lucia [2 ]
Ortiga-Carvalho, Tania Maria [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Ctr Ciencias Saude, Lab Endocrinol Mol, Inst Biofis Carlos Chagas Filho, BR-21949900 Rio De Janeiro, Brazil
[2] Univ Fed Rio de Janeiro, Hosp Univ Clementino Fraga Filho, BR-21949900 Rio De Janeiro, Brazil
来源：
JOURNAL OF ENDOCRINOLOGY | 2012年 / 215卷 / 02期
关键词：
SONIC-HEDGEHOG GENE; HORMONE DEFICIENCY; RATHKES POUCH; ANTERIOR-PITUITARY; HOMEODOMAIN FACTOR; GLAND DEVELOPMENT; THYROID-HORMONE; BETA-GENE; IN-VITRO; MUTATIONS;
D O I：
10.1530/JOE-12-0229
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pituitary organogenesis is a highly complex and tightly regulated process that depends on several transcription factors (TFs), such as PROP1, PIT1 (POU1F1), HESX1, LHX3 and LHX4. Normal pituitary development requires the temporally and spatially organised expression of TFs and interactions between different TFs, DNA and TF co-activators. Mutations in these genes result in different combinations of hypopituitarism that can be associated with structural alterations of the central nervous system, causing the congenital form of panhypopituitarism. This review aims to elucidate the complex process of pituitary organogenesis, to clarify the role of the major TFs, and to compile the lessons learned from functional studies of TF mutations in panhypopituitarism patients and TF deletions or mutations in transgenic animals. © 2012 Society for Endocrinology.
引用
收藏
页码：239 / 245
页数：7
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