Chromatin organizer SATB1 is an important determinant of T-cell differentiation

被引：31

作者：

Burute, Mithila ^{[1
,2
]}

Gottimukkala, Kamal ^{[1
]}

Galande, Sanjeev ^{[1
,2
]}

机构：

[1] Indian Inst Sci Educ & Res, Ctr Excellence Epigenet, Pune 411021, Maharashtra, India

[2] Natl Ctr Cell Sci, Pune, Maharashtra, India

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2012年 / 90卷 / 09期

关键词：

SATB1; T helper cells; Wnt signaling; regulatory T cells; DOMAIN-MEDIATED DIMERIZATION; BETA-CATENIN; TRANSCRIPTION FACTOR; FUNCTIONAL INTERACTION; BINDING PROTEIN; SELF-TOLERANCE; MULTIPLE GENES; MINOR-GROOVE; DNA-BINDING; EXPRESSION;

D O I：

10.1038/icb.2012.28

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

T-cell development and differentiation is coordinated by a multitude of signaling molecules and transcription factors that impart distinct functional properties to progenitors. In this review, we focus on the role of the T lineage-enriched chromatin organizer and regulator SATB1 in T-cell differentiation. SATB1 mediates Wnt signaling by recruiting beta-catenin to its genomic targets and coordinates T helper type 2 (T(H)2) differentiation by positively regulating GATA-3. In contrast, maintenance of regulatory T cell (Treg) functions are dependent on inhibition of SATB1-mediated modulation of global chromatin organization. We discuss how regulation of the activity of SATB1 has a critical role in driving these two important differentiation pathways in T cells. Immunology and Cell Biology (2012) 90, 852-859; doi:10.1038/icb.2012.28; published online 19 June 2012

引用

页码：852 / 859

页数：8

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