Vasoactive intestinal peptide has a direct positive inotropic effect on isolated human myocardial trabeculae

被引：13
|
作者：
Opgaard, OS
Knutsson, M
de Vries, R
Tom, B
Saxena, PR
Edvinsson, L
机构：
[1] Erasmus Univ, Dept Pharmacol, NL-3000 DR Rotterdam, Netherlands
[2] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden
来源：
CLINICAL SCIENCE | 2001年 / 101卷 / 06期
关键词：
inotropic agents; PAC(1) receptor; vasoactive intestinal peptide; VPAC(1) receptor; VPAC(2) receptor;
D O I：
10.1042/CS20010076
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The aim of the present study was to assess the inotropic effects of vasoactive intestinal peptide (VIP) on isolated myocardial trabeculae from the right atrium and the left ventricle of human hearts. Furthermore, using reverse transcriptase-PCR, we wanted to determine the presence of mRNAs encoding the three cloned human VIP receptors, VPAC(1), VPAC(2) and PAC(1). The trabeculae were paced at 1.0 Hz in tissue baths, and changes in isometric contractile force upon exposure to agonist were studied. VIP had a potent positive inotropic effect in some of the atrial and ventricular trabeculae tested, This effect was almost completely blocked by the VIP-receptor antagonist VIP-(6-28). mRNAs encoding the human VPAC(1), VPAC(2) and PAC(1) receptors were detected in human myocardial trabeculae from both the right atrium and the left ventricle. In conclusion, VIP has a direct positive inotropic effect in both the atria and the ventricles of the human heart. The presence of mRNAs for the VPAC(1), VPAC(2) and PAC(1) receptors suggest that VIP may mediate its effect via these receptors.
引用
收藏
页码：637 / 643
页数：7
相关论文
共 50 条
  • [31] Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens
    Li, Bo
    Zou, Yunchun
    Li, Liwen
    Deng, Hongwei
    Mi, Wei
    Wang, Xing
    Yin, Ximin
    BMC OPHTHALMOLOGY, 2019, 19 (01)
  • [32] Vasoactive intestinal peptide enhances wound healing and proliferation of human bronchial epithelial cells
    Guan, Cha-Xiang
    Zhang, Min
    Qin, Xiao-Qun
    Cui, Yan-Ru
    Luo, Zi-Qiang
    Bai, Hong-Bo
    Fang, Xiang
    PEPTIDES, 2006, 27 (12) : 3107 - 3114
  • [33] VASOACTIVE-INTESTINAL-PEPTIDE (VIP) MODULATES EARLY EVENTS OF MIGRATION IN HUMAN KERATINOCYTES
    WOLLINA, U
    KNOPF, B
    INTERNATIONAL JOURNAL OF ONCOLOGY, 1993, 2 (02) : 229 - 232
  • [34] HUMAN INTRAEPITHELIAL LYMPHOCYTES - IMMUNOMODULATION AND RECEPTOR-BINDING OF VASOACTIVE-INTESTINAL-PEPTIDE
    ROBERTS, AI
    PANJA, A
    BROLIN, RE
    EBERT, EC
    DIGESTIVE DISEASES AND SCIENCES, 1991, 36 (03) : 341 - 346
  • [35] Vasoactive intestinal peptide receptor subtypes and signalling pathways involved in relaxation of human stomach
    Severi, C.
    Tattoli, I.
    Corleto, V. D.
    Maselli, M. A.
    Trisolini, P.
    Delle Fave, G.
    NEUROGASTROENTEROLOGY AND MOTILITY, 2006, 18 (11) : 1009 - 1018
  • [36] Vasoactive intestinal peptide causes nitric oxide-dependent pulmonary vasodilation in isolated rat lung
    Iwabuchi, S
    Ono, S
    Tanita, T
    Koike, K
    Fujimura, S
    RESPIRATION, 1997, 64 (01) : 54 - 58
  • [37] THE EFFECT OF DIETARY-SODIUM ON THE CONCENTRATIONS OF VASOACTIVE-INTESTINAL-PEPTIDE IN PLASMA AND LUNG
    YE, VZC
    DUGGAN, KA
    CHEST, 1995, 108 (02) : 535 - 538
  • [38] SOMATOSTATIN DOES NOT BLOCK THE EFFECT OF VASOACTIVE-INTESTINAL-PEPTIDE ON BILE SECRETION IN MAN
    NYBERG, B
    ANGELIN, B
    EINARSSON, K
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1992, 22 (01) : 60 - 66
  • [39] The effect of pituitary adenylate cyclase-activating peptide-38 and vasoactive intestinal peptide in cluster headache
    Vollesen, Anne Luise H.
    Snoer, Agneta
    Chaudhry, Basit
    Petersen, Anja Sofie
    Hagedorn, Andreas
    Hoffmann, Jan
    Jensen, Rigmor H.
    Ashina, Messoud
    CEPHALALGIA, 2020, 40 (13) : 1474 - 1488
  • [40] VASOACTIVE-INTESTINAL-PEPTIDE STIMULATES IMMUNOGLOBULIN PRODUCTION AND GROWTH OF HUMAN B-CELLS
    ISHIOKA, C
    YOSHIDA, A
    KIMATA, H
    MIKAWA, H
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1992, 87 (03) : 504 - 508
12345