γ-secretase inhibitors: Notch so bad

被引：33

作者：

Grosveld, Gerard C. ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Memphis, TN 38105 USA

来源：

NATURE MEDICINE | 2009年 / 15卷 / 01期

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; DIFFERENTIATION; ACTIVATION; MUTATIONS; PATHWAYS; ALLELES; GENES; CELLS;

D O I：

10.1038/nm0109-20

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

γ-secretase inhibitors inhibit Notch, a transmembrane receptor that drives many cases of T cell acute lymphoblastic leukemia—but there are safety concerns with such drugs. Combining these inhibitors with glucocorticoids could provide a more effective and safer approach (pages 50–58).

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收藏

页码：20 / 21

页数：3

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