Green tea and its catechins inhibit breast cancer xenografts

被引：106

作者：

Sartippour, MR

Heber, D

Ma, JY

Lu, QY

Go, VL

Nguyen, M

机构：

[1] Univ Calif Los Angeles, Dept Surg, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Ctr Human Nutr, Los Angeles, CA 90095 USA

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2001年 / 40卷 / 02期

关键词：

D O I：

10.1207/S15327914NC402_11

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Investigators have shown that green tea may, decrease the risk of cancer. It is widely accepted that the main active component of green tea is epigallocatechin-3-gallate (EGCG). In this study, we examined the effect of green tea on breast cancer growth and endothelial cells in in vitro assays and in animal models. Furthermore, we compared the potency of the different catechin components of green tea extract (GTE), including EGCG. Our data showed that mixed GTE and its individual catechin components were effective in inhibiting breast cancer and endothelial cell proliferation. In mouse experiments, GTE suppressed xenograft size and decreased the tumor vessel density. Our results demonstrated the value of all catechins and argued for the use of a mixed GTE as a botanical dietary supplement, rather than purified EGCG, in future clinical trials.

引用

页码：149 / 156

页数：8

共 59 条

[1] Epigallocathechin-3 gallate selectively inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of sis-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172) [J].