Evaluation of epicardial fat tissue thickness in patients with Hashimoto thyroiditis

被引:34
作者
Asik, Mehmet [1 ]
Sahin, Sinan [2 ]
Ozkul, Faruk [3 ]
Anaforoglu, Inan [4 ]
Ayhan, Semiha [4 ]
Karagol, Sukriye [5 ]
Gunes, Fahri [6 ]
Algun, Ekrem [4 ]
机构
[1] Canakkale Onsekiz Mart Univ, Dept Endocrinol & Metab, Fac Med, Canakkale, Turkey
[2] Numune Educ & Res Hosp, Dept Cardiol, Trabzon, Turkey
[3] Numune Educ & Res Hosp, Dept Gen Surg, Trabzon, Turkey
[4] Numune Educ & Res Hosp, Dept Endocrinol & Metab, Trabzon, Turkey
[5] Numune Educ & Res Hosp, Dept Gen Med, Trabzon, Turkey
[6] Canakkale Onsekiz Mart Univ, Dept Gen Med, Fac Med, Canakkale, Turkey
关键词
INTIMA-MEDIA THICKNESS; CORONARY-ARTERY-DISEASE; INDEPENDENT RISK-FACTOR; SUBCLINICAL HYPOTHYROIDISM; ADIPOSE-TISSUE; METABOLIC SYNDROME; EUTHYROID SUBJECTS; CAROTID-ARTERY; HEART-DISEASE; ATHEROSCLEROSIS;
D O I
10.1111/cen.12176
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective Hypothyroidism, whether overt or subclinical, has multiple effects on the cardiovascular system. Epicardial fat tissue (EFT) is closely related to cardiovascular disorders and atherosclerosis. Our study aimed to assess EFT thickness and carotid artery intima-media thickness (CIMT) in patients with Hashimoto's thyroiditis (HT) displaying overt and subclinical hypothyroidism (SCH). Design and patients The study included 33 patients with SCH and 24 patients with overt hypothyroidism (OH) with HT as well as 32 healthy controls. EFT thickness, CIMT, thyroid hormone levels and lipid parameters were measured in all subjects. Correlation analysis and linear regression analysis were performed for EFT thickness. Results Mean EFT thickness was 2.89 +/- 0.38, 3.53 +/- 0.92 and 4.56 +/- 1.61mm in control, SCH and OH groups, respectively (P < 0.001). EFT thickness of OH patients was high compared with SCH and control subjects (P < 0.01 and < 0.001, respectively). CIMT of OH patients was high compared with SCH and control subjects (P < 0.01 and < 0.001, respectively). In addition, EFT was significantly thicker in SCH patients than in controls (P < 0.05). Correlation analysis showed that EFT thickness was significantly positively correlated with CIMT, age, body mass index, systolic blood pressure, thyroid-stimulating hormone, total and LDL cholesterol and triglyceride and negatively correlated with free T4. In the regression analysis, EFT thickness retained its independent and positive association with CIMT, patient group (particularly OH) and systolic blood pressure. Conclusions Epicardial fat tissue thickness may be a useful indicator of early atherosclerosis in SCH and OH patients with HT.
引用
收藏
页码:571 / 576
页数:6
相关论文
共 28 条
  • [1] Subclinical atherosclerosis and hyperandrogenemia are independent risk factors for increased epicardial fat thickness in patients with PCOS and idiopathic hirsutism
    Cakir, Evrim
    Dogan, Mehmet
    Topaloglu, Oya
    Ozbek, Mustafa
    Cakal, Erman
    Vural, Mustafa Gokhan
    Yeter, Ekrem
    Delibasi, Tuncay
    [J]. ATHEROSCLEROSIS, 2013, 226 (01) : 291 - 295
  • [2] Hypothyroidism and atherosclerosis
    Cappola, AR
    Ladenson, PW
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (06) : 2438 - 2444
  • [3] CICCONE MM, 2010, BMC CARDIOVASC DISOR, V28, P10
  • [4] Carotid artery intima media thickness is inversely related to serum free thyroxine in euthyroid subjects
    Dullaart, Robin P. F.
    de Vries, Rindert
    Roozendaal, Carolien
    Kobold, Anneke C. Muller
    Sluiter, Wim J.
    [J]. CLINICAL ENDOCRINOLOGY, 2007, 67 (05) : 668 - 673
  • [5] Thyroid disease and lipids
    Duntas, LH
    [J]. THYROID, 2002, 12 (04) : 287 - 293
  • [6] Carotid intima-media thickness and coronary heart disease risk factors
    Gnasso, A
    Irace, C
    Mattioli, PL
    Pujia, A
    [J]. ATHEROSCLEROSIS, 1996, 119 (01) : 7 - 15
  • [7] Subclinical hypothyroidism is an independent risk factor for atherosclerosis and myocardial infarction in elderly women: The Rotterdam study
    Hak, AE
    Pols, HAP
    Visser, TJ
    Drexhage, HA
    Hofman, A
    Witteman, JCM
    [J]. ANNALS OF INTERNAL MEDICINE, 2000, 132 (04) : 270 - +
  • [8] Holaj R, 2003, CAN J CARDIOL, V19, P670
  • [9] Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: A new indicator of cardiovascular risk
    Iacobellis, G
    Ribaudo, MC
    Assael, F
    Vecci, E
    Tiberti, C
    Zappaterreno, A
    Di Mario, U
    Leonetti, F
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (11) : 5163 - 5168
  • [10] Epicardial fat from echocardiography: A new method for visceral adipose tissue prediction
    Iacobellis, G
    Assael, F
    Ribaudo, MC
    Zappaterreno, A
    Alessi, G
    Di Mario, U
    Leonetti, F
    [J]. OBESITY RESEARCH, 2003, 11 (02): : 304 - 310