Thymosin alpha 1 and HIV-1: recent advances and future perspectives

被引：47

作者：

Matteucci, Claudia ^{[1
]}

Grelli, Sandro ^{[1
]}

Balestrieri, Emanuela ^{[1
]}

Minutolo, Antonella ^{[1
]}

Argaw-Denboba, Ayele ^{[1
]}

Macchi, Beatrice ^{[2
]}

Sinibaldi-Vallebona, Paola ^{[1
,3
]}

Perno, Carlo Federico ^{[1
]}

Mastino, Antonio ^{[3
,4
]}

Garaci, Enrico ^{[1
,5
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med & Surg, Via Montepellier 1, I-00133 Rome, Italy

[2] Univ Roma Tor Vergata, Dept Syst Med, Via Montepellier 1, I-00133 Rome, Italy

[3] CNR, Inst Translat Pharmacol, Via Fosso Cavaliere 100, I-00133 Rome, Italy

[4] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Via F Stagno dAlcontres 31, I-98166 Messina, Italy

[5] IRCSS San Raffaele Pisana, Sci Inst Res Hospitalizat & Hlth Care, Via Val Cannuta 247, I-00166 Rome, Italy

来源：

FUTURE MICROBIOLOGY | 2017年 / 12卷 / 02期

关键词：

ART; CD8 antiviral factor; HIV; immune dysfunction; immune reconstitution; RECONSTITUTION INFLAMMATORY SYNDROME; RECEPTOR EXCISION CIRCLES; CD8(+) T-CELLS; IMMUNE RECONSTITUTION; ANTIRETROVIRAL THERAPY; IN-VITRO; COMBINATION THERAPY; HUMAN-LYMPHOCYTES; INTERFERON-ALPHA; MODEL MEMBRANES;

D O I：

10.2217/fmb-2016-0125

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In spite of the consistent benefits for HIV-1 infected patients undergoing antiretroviral therapy, a complete immune reconstitution is usually not achieved. Actually, antiretroviral therapy may be frequently accompanied by immunological unresponsiveness, persistent inflammatory conditions and inefficient cytotoxic T-cell response. Thymosin alpha 1 is a thymic peptide that demonstrates a peculiar ability to restore immune system homeostasis in different physiological and pathological conditions (i.e., infections, cancer, immunodeficiency, vaccination and aging) acting as multitasking protein depending on the host state of inflammation or immune dysfunction. This review reports the present knowledge on the in vitro and in vivo studies concerning the use of thymosin alpha 1 in HIV-1 infection. Recent findings and future perspectives of therapeutic intervention are discussed.

引用

页码：141 / 155

页数：15

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