Au(I)/Ag(I)-Catalyzed Cascade Approach for the Synthesis of Benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinones

被引：30

作者：

Ji, Xun ^{[1
,2
]}

Zhou, Yu ^{[1
]}

Wang, Jinfang ^{[1
]}

Zhao, Linxiang ^{[2
]}

Jiang, Hualiang ^{[1
,2
]}

Liu, Hong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 09期

基金：

中国国家自然科学基金;

关键词：

TYROSINE KINASE INHIBITOR; CONCISE TOTAL-SYNTHESIS; GOLD CATALYSIS; BIOLOGICAL EVALUATION; POTENT; DERIVATIVES; DESIGN; CYCLOISOMERIZATION; CYCLIZATION; DISCOVERY;

D O I：

10.1021/jo400228g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and facile Au(I)/Ag(I)-catalyzed cascade method has been developed for one-pot synthesis of the complex polycylic heterocycles benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinone derivatives through treatment of the substituted 2-(1H-benzo[d]imidazol-2-yl)anilines with 4-pentynoic acid or 5-hexynoic acid. The strategy features a Au(I)/Ag(I)-catalyzed one-pot cascade process involving the formation of three new C-N bonds in high yields, and with broad a substrate scope.

引用

页码：4312 / 4318

页数：7

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