CD83 expression influences CD4+ T cell development in the thymus

被引:190
作者
Fujimoto, Y [1 ]
Tu, LL [1 ]
Miller, AS [1 ]
Bock, C [1 ]
Fujimoto, M [1 ]
Doyle, C [1 ]
Steeber, DA [1 ]
Tedder, TF [1 ]
机构
[1] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA
关键词
D O I
10.1016/S0092-8674(02)00673-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4(+) T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83(-/-)) mice had a specific block in CD4(+) single-positive thymocyte development without increased CD4(+)CD8(+) double- or CD8(+) single-positive thymocytes. This resulted in a selective 75%-90% reduction in peripheral CD4(+) T cells, predominantly within the naive subset. Wild-type thymocytes and bone marrow stem cells failed to differentiate into mature CD4(+) T cells when transferred into CD83(-/-) mice, while CD83(-/-) thymocytes and stem cells developed normally in wild-type mice. Thereby, CD83 expression represents an additional regulatory component for CD4(+) T cell development in the thymus.
引用
收藏
页码:755 / 767
页数:13
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