CD83 expression influences CD4+ T cell development in the thymus

被引：190

作者：

Fujimoto, Y ^{[1
]}

Tu, LL ^{[1
]}

Miller, AS ^{[1
]}

Bock, C ^{[1
]}

Fujimoto, M ^{[1
]}

Doyle, C ^{[1
]}

Steeber, DA ^{[1
]}

Tedder, TF ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA

来源：

CELL | 2002年 / 108卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(02)00673-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4(+) T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83(-/-)) mice had a specific block in CD4(+) single-positive thymocyte development without increased CD4(+)CD8(+) double- or CD8(+) single-positive thymocytes. This resulted in a selective 75%-90% reduction in peripheral CD4(+) T cells, predominantly within the naive subset. Wild-type thymocytes and bone marrow stem cells failed to differentiate into mature CD4(+) T cells when transferred into CD83(-/-) mice, while CD83(-/-) thymocytes and stem cells developed normally in wild-type mice. Thereby, CD83 expression represents an additional regulatory component for CD4(+) T cell development in the thymus.

引用

页码：755 / 767

页数：13

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